Relationship of Peritoneal Solute Transport Rate With VEGF in Children Undergoing Peritoneal Dialysis

• Conditions: Peritoneal Dialysis

• Registration Number: NCT00516061
• Lead Sponsor: Samsung Medical Center

Brief Summary

Vascular endothelial growth factor(VEGF) appears to play a central role in the process leading to peritoneal angiogenesis and increased level of VEGF may contribute to high peritoneal small-solute transport rate (PSTR) in continuous ambulatory peritoneal dialysis (CAPD) patients in adult. In children, lymphatic absorption of solute is greater than adult. VEGF-C is related to lymphogenesis, but its role in peritoneal solute transport rate is not known. In this study, we evaluated possible relationship between dialysate VEGF and VEGF-C levels and PSTR in children.

Detailed Description

There was significant correlation between dialysate VEGF165 and VEGF-C levels and significant correlation was noted between dialysate VEGF165 and PSTR. Interestingly, dialysate VEGF-C levels had significant correlation with PSTR. High PSTR seems to be related to elevated VEGF-C and VEGF.

Study Timeline

• Status Verified: 2006-12
• Study Start: 2006-12
• Study First Submitted: 2007-08-13
• Study First Submitted QC: 2007-08-13
• Last Update Submitted: 2007-08-13
• Study First Posted: 2007-08-14
• Last Update Posted: 2007-08-14
• Study Completion: 2007-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• chronic renal failure
• children
• peritoneal dialysis

Exclusion Criteria

• acute illness

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Trial Locations

Locations (1)

Samsung Medical Center; 🇰🇷 Seoul, Korea, Republic of