Morphometric correlates and predictors of impaired gait and balance in Parkinson’s Disease-a pilot study

• Conditions: G20; Parkinson disease

• Registration Number: DRKS00003290
• Lead Sponsor: Medizinische Universität InnsbruckUniversitätsklinik für Neurologie

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2011-10-05
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

A) Inclusion criteria patients: 1) the subject is aged between 40 and 85 years; 2) clinical diagnosis of PD obtained by a neurologist according to published clinical diagnostic criteria; 3) the patient has the ability to communicate well with the investigator and comply with the requirements of the study; 4) written informed consent is obtained.
B) Inclusion criteria healthy controls: 1) the subject is aged between 40 and 85 years; 2) written informed consent is obtained. 3) The subject has the ability to communicate well with the investigator and comply with the requirements of the entire study

Exclusion Criteria

BA Exclusion criteria patients: 1) History of other neurological or psychiatric disorders or conditions; 2) The subject has a history of alcohol, narcotic, or any other drug abuse as defined by the Diagnostic and Statistical Manual of the American Psychiatric Association, 4th Edition (DSM IV). 3) the subject is pregnant. 4) the subject is unsuitable for an MRI study (e.g. Pacemakers; medical or bio-stimulation implants which are contraindicated for MRI scans and which may include vagus nerve stimulators, implantable cardioverter-defibrillators, loop recorders, insulin pumps, cochlear implants)
B) Exclusion criteria healthy controls: 1) History of neurological or psychiatric disorders or conditions; 2) The subject has a history of alcohol, narcotic, or any other drug abuse as defined by the Diagnostic and Statistical Manual of the American Psychiatric Association, 4th Edition (DSM IV). 3) the subject is pregnant. 4) the subject is unsuitable for an MRI study (e.g. Pacemakers; medical or bio-stimulation implants which are contraindicated for MRI scans and which may include vagus nerve stimulators, implantable cardioverter-defibrillators, loop recorders, insulin pumps, cochlear implants).

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Evaluation of morphometric correlates and predictors of impaired gait and balance in Parkinson’s Disease in 3.0 Tela MRI.

Secondary Outcome Measures

Name	Time	Method
The aims of this study are (i) to assess changes occurring in patients with PD compared to healthy controls, (ii) to discriminate patients with PD from healthy controls and (iii) to assess changes occurring in patients with the PIGD subtype of PD compared to PD patients presenting with a non-PIGD subtype (iv) to determine progression of morphometric MR-indices using multimodal MRI sensitive to complementary tissue characteristics.