Increased thrombogenicity in patients with atherosclerosis of the peripheral arteries of the lower extremities: a case-control study.

Completed

• Conditions: Atherosclerosis; Hypercoagulability; peripheral arterial disease; 10003216

• Registration Number: NL-OMON38884
• Lead Sponsor: Medisch Universitair Ziekenhuis Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 80

Inclusion Criteria

Patients who have entered the PAD study, as PAD the novo with an EAI<0,9, and did (cases) or did not (controls) reach an endpoint within 1 year of follow-up.

Exclusion Criteria

- Patients with known coagulopathies (coagulation disorders)
- Pregnancy
- Chronic Inflammatory Disorders
- Anti-phospholipid syndrome
- Malignancies
- Systemic anticoagulation (acenocoumarol, fenprocoumon, dabigatran, rivaroxaban)

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>1. Thrombogram* measurement in full-blood and PPP<br /><br>2. Flow chamber assay<br /><br>3. Thromboelastometry with added tPA<br /><br>4. Measurement of Mi-RNA*s </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>N/A</p><br>