Interval Training Study in Psoriatic Arthritis

Not Applicable

Completed

• Conditions: Psoriatic Arthritis
• Interventions: Behavioral: interval training

• Registration Number: NCT02995460
• Lead Sponsor: Norwegian University of Science and Technology

Brief Summary

Psoriatic arthritis is a chronical inflammatory disease characterized by pain and reduced physical function. Patients have a higher risk of cardiovascular disease and a higher body mass index.

A pilot study in patients with rheumatoid arthritis has shown positive effect on inflammation after 12 weeks of high-intensity interval training.

The primary aim of this study is to determine whether high-intensity interval training affects the disease activity in psoriatic arthritis. This intervention is believed to result in benefits in terms of inflammation, body composition and risk factors for cardiovascular disease.

Detailed Description

Not available

Study Timeline

• Study Start: 2013-01
• Primary Completion: 2015-12
• Study Completion: 2015-12
• Study First Submitted: 2016-12-14
• Study First Submitted QC: 2016-12-14
• Study First Posted: 2016-12-16
• Status Verified: 2018-11
• Last Update Submitted: 2018-11-08
• Last Update Posted: 2018-11-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 67

Inclusion Criteria

• fulfilling the CASPAR criteria of psoriatic arthritis
• ability to exercise.

Exclusion Criteria

• Inability to exercise
• very high disease Activity
• unstable ischemic cardiovascular disease
• severe pulmonary disease
• pregnancy
• breastfeeding
• drug- and alcohol addictions

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
interval training	interval training	4x4 high intensity interval training was performed on a stationary bicycle with a supervisor twice a week and by one self-training a week.

Primary Outcome Measures

Name	Time	Method
Patient global assesment (PGA)	Baseline, 3 months (right after intervention), 9 months	PGA is measured as a change between timepoints. PGA is registered by the patient on a visual analog scale.
Maximal oxygen uptake (VO2 max)	Baseline, 3 months (right after intervention), 9 months	The VO2 max is measured as a change between timepoints

Secondary Outcome Measures

Name	Time	Method
Total lean mass	Baseline, 3 months (right after intervention), 9 months	Total lean mass is measured as a change between timepoints and is measured by dual energy x-ray absorptiometry (DXA).
Total body fat	Baseline, 3 months (right after intervention), 9 months	Total body fat is measured as a change between timepoints and is measured by dual energy x-ray absorptiometry (DXA).