Individuals with Periodontitis with or without Down Syndrome
- Conditions
- PeriodontitisC10.597.606.360.220
- Registration Number
- RBR-5syrc3r
- Lead Sponsor
- Faculdade de Odontologia do Campus de Araçatuba - Universidade Estadual Paulista Júlio de Mesquita Filho
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- Not specified
Forty-five individuals will be recruited and allocated to one of three study groups, according to the inclusion criteria: group control (C): fifteen with systemically healthy individuals, without Down syndrome (DS) and who qualify in the following definition of periodontal and gingival health: no loss of clinical attachment, with probing depth of up to 3 mm, bleeding in less than 10% of sites, no radiographic bone loss and age between 19 and 35 years. Group P: fifteen systemically healthy individuals without DS; diagnosed with grade C, stage III or IV periodontitis and aged between 19 and 35 years. DS group: fifteen systemically healthy individuals, diagnosed with DS and periodontitis; as a manifestation of systemic diseases and aged between 19 and 35 years
Exclusion criteria will be: current or past smoking habit; pregnancy or breastfeeding; use of antibiotic or anti-inflammatory medication in the 6-month period prior to the study; previous periodontal treatment within 6 months before sample collection; diabetes or other systemic diseases that affect the immuno-inflammatory process
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Comparative analysis of the immuno-inflammatory profile of patients with periodontitis with and without Down Syndrome and with those of individuals without periodontal disease.<br>
- Secondary Outcome Measures
Name Time Method Analyze the correlation of the analyzed biomarkers with the degree of attachment loss and periodontal disease.<br>