NCT04952285已完成不适用
The Efficacy and Safety of the Loading Dose of Tranexamic Acid in Scoliosis Surgery During Perioperative
Second Affiliated Hospital, School of Medicine, Zhejiang University0 个研究点目标入组 207 人开始时间: 2015年1月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 207
- 主要终点
- Intraoperative blood loss
研究概览
简要总结
This study intends to make full use of the advantage of spinal orthopedic surgery in our medical center.Analyze the blood loss and blood coagulation function and the influence of safety of load dose tranexamic acid (TXA) in scoliosis surgery during perioperative.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age:18-60 years old
- •American Society of Anesthesiologists (ASA):I-II
- •The spinal orthopedic undergoing elective surgery
排除标准
- •Severe cardiopulmonary dysfunction
- •Blood coagulation dysfunction
- •Disorders of liver and kidney function
- •Tranexamic acid allergies
- •The history of pulmonary embolism and venous thrombosis of lower limbs
- •Anticoagulant drugs and nonsteroidal anti-inflammatory drugs in 7 days
结局指标
主要结局
Intraoperative blood loss
时间窗: At the end of the surgery
Intraoperative blood loss
Incision drainage Incision drainage Incision drainage after surgery
时间窗: 24 hours after surgery
Incision drainage after surgery
次要结局
- APTT(Within 1 week before surgery；1 day after surgery)
- Autologous blood doping(At the end of the surgery)
- red blood cell transfusion(At the end of the surgery)
- Plasma infusion(At the end of the surgery)
- HB(Within 1 week before surgery；1 day after surgery)
- WBC(Within 1 week before surgery；1 day after surgery)
- PTL(Within 1 week before surgery；1 day after surgery)
- PT(Within 1 week before surgery；1 day after surgery)
- INR(Within 1 week before surgery；1 day after surgery)
研究者
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