Methylprednisolone and Hyaluronic Acid Versus Each Agent Alone to Control Post-extraction Complications of Impacted Mandibular Third Molar
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 72
- 试验地点
- 1
- 主要终点
- Size of edema will be assessed from finial angle and Travis of ear to mental ala of Nes and mouth angle
研究概览
简要总结
Impacted mandibular 3rd molar will be extracted in all patients, then patients will be divided, according to material placed in extraction socket into 3 groups: control, hyaluronic acid and honey. Then post extraction complications will be evaluated
详细描述
Impacted Mandibular third molar will be extracted under local anesthesia Through standard surgical flap elevation, after extraction and wound irrigation a material facilitate healing will be placed. According to material will be placed patients will be divide into 3 group: control ( no material, second group hyaluronic acid, third group ( honey).. then wound will be closed. Postoperative pain ( through visual analog scale) , edema, total dose of analgesic, mandibular movement (interincisal distance in mm) will be evaluated preoperative, 1,2,3,7, and 10 day after extraction
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 35 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •healthy patients
- •patient has impacted 3rd molar
排除标准
- •medically compromised patients Heavy smoking patients
研究组 & 干预措施
Normal saline
Normal saline irrigation after extraction and No drug placed in tooth socket
干预措施: Normal saline (Drug)
Gengigel
Gengigel (Hyaluronic acid) placed after extraction
干预措施: Hyaluronic acid (Drug)
Methylprednisolone
Methylprednisolone will be given intravenous to a patient half an hour before the surgery
干预措施: Methylprednisolone (Drug)
Methylprednisolone and Gengigel
Methylprednisolone will be given intravenous to a patient half an hour before the surgery and Gengigel (Hyaluronic acid) placed after extraction
干预措施: Methylprednisolone and Hyaluronic acid (Drug)
结局指标
主要结局
Size of edema will be assessed from finial angle and Travis of ear to mental ala of Nes and mouth angle
时间窗: 7th day postoperative
Edema measured from gonial angle and Tragus to mental, angle of mouth, ala of nose, and lateral canthus of eye respectively
Interincisal distance
时间窗: 7th day postoperative
Measuring distance between upper lower anterior teeth in mm
Total amount of analgesic
时间窗: 7th day postoperative
Total amount of analgesic Will be calculated
Assessment of pain using Visual analog scale
时间窗: 7th day
Patient asked to describe pain intensity subjectively on visual analog scale where 0 mean no pain while 10 mean sever pain
次要结局
未报告次要终点
研究者
Alaa Altaweel
Associate professor
Al-Azhar University