Controlling Post-extraction Complications of Impacted Mandibular Third Molar

Not Applicable

Completed

• Conditions: Preventing Postextraction Complication
• Interventions: Drug: Normal saline; Drug: Hyaluronic acid; Drug: Methylprednisolone; Drug: Methylprednisolone and Hyaluronic acid

• Registration Number: NCT04816253
• Lead Sponsor: Al-Azhar University

Brief Summary

Impacted mandibular 3rd molar will be extracted in all patients, then patients will be divided, according to material placed in extraction socket into 3 groups: control, hyaluronic acid and honey. Then post extraction complications will be evaluated

Detailed Description

Impacted Mandibular third molar will be extracted under local anesthesia Through standard surgical flap elevation, after extraction and wound irrigation a material facilitate healing will be placed. According to material will be placed patients will be divide into 3 group: control ( no material, second group hyaluronic acid, third group ( honey).. then wound will be closed. Postoperative pain ( through visual analog scale) , edema, total dose of analgesic, mandibular movement (interincisal distance in mm) will be evaluated preoperative, 1,2,3,7, and 10 day after extraction

Study Timeline

• Study Start: 2021-02-10
• Study First Submitted: 2021-03-23
• Study First Submitted QC: 2021-03-24
• Study First Posted: 2021-03-25
• Primary Completion: 2021-06-20
• Study Completion: 2021-06-20
• Status Verified: 2021-07
• Last Update Submitted: 2021-07-20
• Last Update Posted: 2021-07-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 72

Inclusion Criteria

• healthy patients
• patient has impacted 3rd molar

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Exclusion Criteria

• medically compromised patients Heavy smoking patients

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Normal saline	Normal saline	Normal saline irrigation after extraction and No drug placed in tooth socket
Gengigel	Hyaluronic acid	Gengigel (Hyaluronic acid) placed after extraction
Methylprednisolone	Methylprednisolone	Methylprednisolone will be given intravenous to a patient half an hour before the surgery
Methylprednisolone and Gengigel	Methylprednisolone and Hyaluronic acid	Methylprednisolone will be given intravenous to a patient half an hour before the surgery and Gengigel (Hyaluronic acid) placed after extraction

Primary Outcome Measures

Name	Time	Method
Size of edema will be assessed from finial angle and Travis of ear to mental ala of Nes and mouth angle	7th day postoperative	Edema measured from gonial angle and Tragus to mental, angle of mouth, ala of nose, and lateral canthus of eye respectively
Interincisal distance	7th day postoperative	Measuring distance between upper lower anterior teeth in mm
Total amount of analgesic	7th day postoperative	Total amount of analgesic Will be calculated
Assessment of pain using Visual analog scale	7th day	Patient asked to describe pain intensity subjectively on visual analog scale where 0 mean no pain while 10 mean sever pain

Trial Locations

Locations (1)

Vision college; 🇸🇦 Jeddah, Saudi Arabia