Effects of anti-allergic ophthalmic solutions on chemical mediators in tear fluid and on expression of chemical mediator receptors on conjunctival epithelial cells in patients with allergic conjunctivitis for pre-seasonal therapy - Effects of anti-allergic ophthalmic solutions on chemical mediators in tear fluid and on expression of chemical mediator receptors on conjunctival epithelial cells in patients with allergic conjunctivitis for pre-seasonal therapy

69 cases (Epinastine Intervention Group; 35 cases, Switch from Artificial Tears to Epinastine Intervention Group; 34 cases) were enrolled. As for both groups, expression levels of chemical mediator receptor mRNA on conjunctival epithelial cells were significantly increased at week 12 from the baseline (week 0). As for both groups, levels of chemical mediation in tears were not changed significantly. Through the study period, there were no side effects for both groups.