Analgesic Efficacy of Intravenous Lidocaine and/or Ketamine

Not Applicable

Completed

• Conditions: Postoperative Pain
• Interventions: Drug: Lidocaine,; Drug: association ketamine-lidocaine; Drug: Placebo; Drug: Ketamine

• Registration Number: NCT01439399
• Lead Sponsor: University of Lausanne Hospitals

Brief Summary

The aim of the present study is to evaluate the analgesic benefit of intravenous lidocaine and ketamine in the perioperative period of abdominal surgery.

Detailed Description

Optimal postoperative pain management facilitates rehabilitation immediately after abdominal surgery. Multiple studies have demonstrated that successful postoperative analgesia also reduces perioperative complications and improves patient comfort, thereby providing many benefits for the patient. In acute postoperative pain management intravenous lidocaine and/or ketamine have been advocated because of their morphine-sparing effect.

Study Timeline

• Study Start: 2005-12
• Primary Completion: 2007-07
• Study Completion: 2007-07
• Status Verified: 2011-09
• Study First Submitted: 2011-09-20
• Study First Submitted QC: 2011-09-21
• Last Update Submitted: 2011-09-21
• Study First Posted: 2011-09-23
• Last Update Posted: 2011-09-23

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 52

Inclusion Criteria

• abdominal surgery by laparotomy

Exclusion Criteria

• laparoscopy
• history of chronic pain
• opioid self-administration
• psychiatric disorders
• difficulties with communication
• renal or hepatic dysfunction
• ASA physical status > 3

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Lidocaine	Lidocaine,	Intravenous lidocaine administered preoperatively (anesthesia induction) and postoperatively during 48 hours
Ketamine-Lidocaine	association ketamine-lidocaine	Intravenous association of ketamine and lidocaine administered preoperatively (at anesthesia induction) and postoperatively during 48 hours.
Saline 0,9%	Placebo	Control group
Ketamine	Ketamine	Intravenous ketamine administered preoperatively (anesthesia induction) and postoperatively during 48 hours

Primary Outcome Measures

Name	Time	Method
Cumulative morphine consumption	48 hours	Cumulative morphine consumption over 48 hours postoperatively

Secondary Outcome Measures

Name	Time	Method
Pain scores	48 hours	Pain scores at rest and movement
Mechanical hyperalgesia	48 hours	Mechanical hyperalgesia using pressure algometry
Occurrence of side effects	48 hours	Occurrence of side effects: sedation, nausea, vomiting, itching, nightmares

Trial Locations

Locations (1)

University Hospital Center and University; 🇨🇭 Lausanne, Vaud, Switzerland