Analgesic Efficacy of Intravenous Perfusion of Lidocaine, Ketamine or a Combination After Laparotomy in a Placebo-controlled, Randomized, Double-blind Prospective Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 52
- 试验地点
- 1
- 主要终点
- Cumulative morphine consumption
研究概览
简要总结
The aim of the present study is to evaluate the analgesic benefit of intravenous lidocaine and ketamine in the perioperative period of abdominal surgery.
详细描述
Optimal postoperative pain management facilitates rehabilitation immediately after abdominal surgery. Multiple studies have demonstrated that successful postoperative analgesia also reduces perioperative complications and improves patient comfort, thereby providing many benefits for the patient. In acute postoperative pain management intravenous lidocaine and/or ketamine have been advocated because of their morphine-sparing effect.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •abdominal surgery by laparotomy
排除标准
- •laparoscopy
- •history of chronic pain
- •opioid self-administration
- •psychiatric disorders
- •difficulties with communication
- •renal or hepatic dysfunction
- •ASA physical status > 3
研究组 & 干预措施
Lidocaine
Intravenous lidocaine administered preoperatively (anesthesia induction) and postoperatively during 48 hours
干预措施: Lidocaine, (Drug)
Ketamine
Intravenous ketamine administered preoperatively (anesthesia induction) and postoperatively during 48 hours
干预措施: Ketamine (Drug)
Ketamine-Lidocaine
Intravenous association of ketamine and lidocaine administered preoperatively (at anesthesia induction) and postoperatively during 48 hours.
干预措施: association ketamine-lidocaine (Drug)
Saline 0,9%
Control group
干预措施: Placebo (Drug)
结局指标
主要结局
Cumulative morphine consumption
时间窗: 48 hours
Cumulative morphine consumption over 48 hours postoperatively
次要结局
- Pain scores(48 hours)
- Mechanical hyperalgesia(48 hours)
- Occurrence of side effects(48 hours)
研究者
Joray Florence
Chief Resident
University of Lausanne Hospitals