Aerobic Exercises for Multiple Sclerosis

Not Applicable

Completed

• Conditions: Multiple Sclerosis, Primary Progressive
• Interventions: Other: aerobic exercise

• Registration Number: NCT04545372
• Lead Sponsor: South Valley University

Brief Summary

Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS) .It is the most common neurological disorders affecting young adults.Multiple sclerosis is an autoimmune disease that results in progressive neural degeneration. Cytokines play an important role in the pathogenesis and treatment of MS.

Detailed Description

This research aims to evaluate the effect of aerobic exercises on the immune system anti-inflammatory (IL-10) and pro inflammatory (IL-17) cytokines and its consequences on the functional status in the Multiple Sclerosis patients.

Aerobic exercises are a term to describe planned, structured and repetitive physical activity undertaken over a prolonged period to maintain or improve physical fitness and functional capacity .

Study Timeline

• Study Start: 2015-02-02
• Primary Completion: 2018-08-04
• Study Completion: 2020-08-06
• Study First Submitted: 2020-08-26
• Status Verified: 2020-09
• Study First Submitted QC: 2020-09-03
• Last Update Submitted: 2020-09-03
• Study First Posted: 2020-09-11
• Last Update Posted: 2020-09-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

age ranged from 25 to 45 years. All the patients were remitting relapsing MS according to (revised McDonald criteria.

Duration of MS disease was one to two years before starting of the study. Last attack occurred three months ago. All patients were able to ambulate

Exclusion Criteria

Patients with other neurological deficits , patient with significant orthopedic abnormalities for both lower limbs, patient with contracture , patient with deformities, pregnant females

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
the study group	aerobic exercise	the study group (GA) was treated only by the disease modifying drug (interferon beta-1a) in addition to aerobic exercise.

Primary Outcome Measures

Name	Time	Method
blood analysis	pro inflammatory cytokine IL-17 will be assessed at 90 day	pro inflammatory cytokine IL-17

Trial Locations

Locations (1)

South Valley University, Faculty of Physical Therapy; 🇪🇬 Qina,, Egypt