Effect of Aerobic Exercises on Immune System in Patients With Multiple Sclerosis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- blood analysis
研究概览
简要总结
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS) .It is the most common neurological disorders affecting young adults.Multiple sclerosis is an autoimmune disease that results in progressive neural degeneration. Cytokines play an important role in the pathogenesis and treatment of MS.
详细描述
This research aims to evaluate the effect of aerobic exercises on the immune system anti-inflammatory (IL-10) and pro inflammatory (IL-17) cytokines and its consequences on the functional status in the Multiple Sclerosis patients.
Aerobic exercises are a term to describe planned, structured and repetitive physical activity undertaken over a prolonged period to maintain or improve physical fitness and functional capacity .
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
盲法说明
Double (Participant, Investigator) Single (Outcomes Assessor) Blinding process to participants and care providers was impossible due to the nature of intervention therapy. Data were analyzed by an impartial statistician (outcomes assessor), referring to each arm with an encoded name: Group A (study group) and Group B (control group),
入排标准
- 年龄范围
- 25 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age ranged from 25 to 45 years. All the patients were remitting relapsing MS according to (revised McDonald criteria.
- •Duration of MS disease was one to two years before starting of the study. Last attack occurred three months ago. All patients were able to ambulate
排除标准
- •Patients with other neurological deficits , patient with significant orthopedic abnormalities for both lower limbs, patient with contracture , patient with deformities, pregnant females
研究组 & 干预措施
the study group
the study group (GA) was treated only by the disease modifying drug (interferon beta-1a) in addition to aerobic exercise.
干预措施: aerobic exercise (Other)
the control group
control group (GB)was treated only by the disease modifying drug (interferon beta-1a)
结局指标
主要结局
blood analysis
时间窗: pro inflammatory cytokine IL-17 will be assessed at 90 day
pro inflammatory cytokine IL-17
blood analysis
时间窗: serum anti inflammatory cytokine IL-10, will be assessed at 0 day
serum anti inflammatory cytokine IL-10,
blood analysis
时间窗: serum anti inflammatory cytokine IL-10, wil lbe assessed at 90 day
serum anti inflammatory cytokine IL-10,
blood analysis
时间窗: pro inflammatory cytokine IL-17 will be assessed at 0 day
pro inflammatory cytokine IL-17
次要结局
未报告次要终点
研究者
Nehad Ahmed Youness Abo-zaid
Lecturer of physical therapy
South Valley University