Effect of Aerobic Exercises on Immune System in Patients With Multiple Sclerosis
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Multiple Sclerosis, Primary Progressive
- Sponsor
- South Valley University
- Enrollment
- 30
- Locations
- 1
- Primary Endpoint
- blood analysis
- Status
- Completed
- Last Updated
- 5 years ago
Overview
Brief Summary
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS) .It is the most common neurological disorders affecting young adults.Multiple sclerosis is an autoimmune disease that results in progressive neural degeneration. Cytokines play an important role in the pathogenesis and treatment of MS.
Detailed Description
This research aims to evaluate the effect of aerobic exercises on the immune system anti-inflammatory (IL-10) and pro inflammatory (IL-17) cytokines and its consequences on the functional status in the Multiple Sclerosis patients. Aerobic exercises are a term to describe planned, structured and repetitive physical activity undertaken over a prolonged period to maintain or improve physical fitness and functional capacity .
Investigators
Nehad Ahmed Youness Abo-zaid
Lecturer of physical therapy
South Valley University
Eligibility Criteria
Inclusion Criteria
- •age ranged from 25 to 45 years. All the patients were remitting relapsing MS according to (revised McDonald criteria.
- •Duration of MS disease was one to two years before starting of the study. Last attack occurred three months ago. All patients were able to ambulate
Exclusion Criteria
- •Patients with other neurological deficits , patient with significant orthopedic abnormalities for both lower limbs, patient with contracture , patient with deformities, pregnant females
Outcomes
Primary Outcomes
blood analysis
Time Frame: pro inflammatory cytokine IL-17 will be assessed at 90 day
pro inflammatory cytokine IL-17