NCT01812473已完成不适用
Impact of Hypoalbuminemia on Voriconazole Pharmacokinetics in Critically Ill Adult Patients.
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 35
- 试验地点
- 1
- 主要终点
- Differences in Overall Protein Binding in the Presence of Different Plasma Albumin Concentrations.
研究概览
简要总结
The purpose of this study is to investigate the influence of hypoalbuminemia on the protein binding characteristics of the antifungal drug voriconazole in ICU patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 2 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •treated with voriconazole
排除标准
- 未提供
结局指标
主要结局
Differences in Overall Protein Binding in the Presence of Different Plasma Albumin Concentrations.
时间窗: At steady state plasma concentration of voriconazole (after day 4 of therapy)
At steady state plasma concentrations of voriconazole, a plasma sample is taken to determine the overall protein binding of voriconazole. Equilibrium dialysis is used, followed by liquid chromatography-mass spectrometry.
次要结局
未报告次要终点
研究者
研究点 (1)
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