Association of Polymorphism in Genes Associated With Control of Dopamine Levels in Parkinson's Disease and Tc-99m-Trodat-1 SPECT Imaging.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- Disease severity versus genetic polymorphism
研究概览
简要总结
The study population will include 100 parkinsonian patients in early stage of disease, with total duration not exeeding 5 years.
The patients will undergo neurologic examination and evaluation of disease severity using the unified PD rating scale. Subsequently a brain SPECT will be performed using Tc-99m-Trodat1.
详细描述
The study sample will include 100 Israeli Jewish patients with early idiopathic PD who were not treated with anti-parkinson drugs. The clinical diagnosis will be based on the criteria of the United Kingdom Parkinson Disease Society Brain Bank.5 All patients will undergo Tc-99m-Trodat1 SPECT. The severity of the motor symptoms will be assessed with the Unified PD Rating Scale (UPDRS). Genomic DNA is extracted from peripheral blood leukocytes for genetic analysis.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 35 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Inclusion criteria were
- •early Israeli PD patients
- •Of jewish origin, males or females
- •Undergoing DAT-scan examination in Wolfson medical center at early stage of disease, accompanied by a UPDRS evaluation at that stage,performed by a trained neurologist
- •Patients did not use any type of anti-parkinsonian drug type, at time of DAT-scan performance and UPDRS evaluation
- •DNA sample was obtained
- •Patients were able to sign an informed consent form to participate in this study.
排除标准
- •Patients were excluded if they features secondary parkinsonism or if they were treated with medications that block dopamine receptors.
结局指标
主要结局
Disease severity versus genetic polymorphism
时间窗: 1 year
Correlation of disease severity with polymorphism and with striatal affinity to the DAT ligand.
次要结局
- Severity of PD compared to specific striatal DAT activity as measures by Tc-99m Trodat SPECT.(1 year)
研究者
Mordechai Lorberboym Prof
pI
Wolfson Medical Center