A Study to Evaluate the Effect of Testosterone on Muscle Fractional Synthetic Rate (MK-0000-064)

Recruitment & Eligibility

Inclusion Criteria

Subject is weight stable over the past 3 months
Patient agrees to refrain from consumption of alcohol from 48 hours prior to entering the study
Subject agrees to follow the study restriction of no caffeine while on study
Patient agrees to following the meat-free controlled protein weight-maintaining diet
Patient is willing to avoid strenuous physical activity
Patient has been a nonsmoker for at least 6 months prior to study start

Exclusion Criteria

Subject is currently a regular user of any illicit drugs
Subject has taken androgenic steroids in the previous 12 months
Subject has participated in sports events, resistance exercise training or heavy exercise in the previous month
Subject has prostate cancer
Subject has a history of cancer except basal-cell tumors
Subject has been diagnosed with HIV
Subject has been diagnosed with Hepatitis B or C
Subject uses certain anti-inflammatory drugs such as ibuprofen, arcoxia or celecoxib
Subject uses a blood anticoagulant, such as Coumadin (Warfarin) or high doses of aspirin
Subject is currently taking over the counter supplements such as "muscle builders" or "fat burners"
Subject has an allergy or hypersensitivity to intramuscular testosterone
Subject has sciatica
Subject has donated blood products or has had phlebotomy within 2 months of signing informed consent
Subject has undergone a surgical procedure within 1 month of signing informed consent
Subject is currently participating or has participated in a study with an investigational drug or device

Study & Design

Primary Outcome Measures

Name	Time	Method
Thigh (vastus lateralis) muscle protein fractional synthetic rate one week after dosing with testosterone.	One week

Secondary Outcome Measures

Name	Time	Method
Variability in the muscle fractional synthetic rate measurements.	One week

Recruitment & Eligibility