The enteral environment analysis using the human feces for the chronic liver disease and relative examination with the clinical data, multiple center study.

Not Applicable

• Conditions: Chronic liver disease (nonalcoholic steatohepatitis, nonalcoholic fatty liver disease), healthy volunteer

• Registration Number: JPRN-UMIN000020917
• Lead Sponsor: Yokohama city university gastroenterology and hepatorogy

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2016-02-07
• Study Completion: 2019-09-01
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Complete: follow-up continuing
• Sex: All
• Target Recruitment: 500

Inclusion Criteria

Not provided

Exclusion Criteria

1) Re-registration example to the examination 2) The patients with malignant tumor 3) In addition, the patient who judged an arrangement to the examination if the medical attendant was inappropriate 4) The patients that specimen collection is not possible by dyschezia.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Difference of bacterial flora between healthy volunteer and each chronic liver disease.

Secondary Outcome Measures

Name	Time	Method
Difference of parameters as below between healthy volunteer and each chronic liver disease. Blood: endotoxin, metabolome(bile acid, organic acid, short chain fatty acid, amino acid etc.). Feces: metabolome (bile acid, organic acid, short chain fatty acid, amino acid etc.), mucin Urine: lactulose mannnitol ratio. Comparison of the above items with clinical findings.