ISRCTN17685148Completed未知
Role of amyloid positron emission tomography (PET) imaging in the timely diagnosis of Alzheimer’s disease in patients with underlying depression or vitamin B12/Folate deficiency: feasibility study
Sussex Partnership NHS Foundation Trust0 sites10 target enrollmentStarted: May 20, 2015Last updated:
Conditions
Trial Snapshot
- Phase
- 未知
- Status
- Completed
- Enrollment
- 10
Study Overview
Brief Summary
2016 poster in https://doi.org/10.1016/j.jalz.2016.06.031 (added 23/04/2021) (published 01/07/2016) 2016 abstract in https://doi.org/10.1016/j.jalz.2016.06.1890 (added 23/04/2021) (published 01/07/2016)
Study Design
- Study Type
- Interventional
Eligibility Criteria
- Sex
- All
Inclusion Criteria
- •1. Patients aged >40 referred to memory clinic
- •2. Presence of memory complaint suspicious of AD
- •3. Below normal scores on cognitive testing (CAMCOG, ACE III or sMMSE scores below the normal range)
- •4. Presence of specific co-morbid illnesses known to affect cognition and to complicate the diagnosis of Alzheimer’s disease, namely depression and vitamin B12 deficiency
- •5. MRI and/or CT brain scanning done previously as part of routine diagnostic process
Exclusion Criteria
- •1. Evidence obtained from history, physical examination or investigations which clearly support the diagnosis of conditions such as vascular dementia, dementia with Lewy bodies and frontotemporal dementia
- •2. Lack of ability to give informed consent
- •3. Inability to undertake PET scanning or previous allergic reaction to injected investigative nuclear medicine tracers
- •4. Positive pregnancy test in premenopausal women and breastfeeding
- •5. Inability to undertake PET scanning
Investigators
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