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mifenovir effectiveness in the treatment of COVID-19

Phase 3
Conditions
Covid-19.
Covid-19
U07.1
Registration Number
IRCT20200322046833N1
Lead Sponsor
Center for Progress and Development of Iran
Brief Summary

Not available

Detailed Description

Not available

Recruitment & Eligibility

Status
Complete
Sex
All
Target Recruitment
100
Inclusion Criteria

Age >18 years old
Patients with a probable and definitive diagnosis of COVID-19 who are candidates for hospitalization and receiving antiviral regimens.
Presence of at least one clinical sign (including fever, chills, cough, myalgia) with positive virologic specimen or imaging findings for COVID-19

Exclusion Criteria

Patient or fellows' dissatisfaction with entering or continuing the study
History or any signs of hypersensitivity to umifenovir
Pregnancy and lactation

Study & Design

Study Type
interventional
Study Design
Not specified
Primary Outcome Measures
NameTimeMethod
Clinical improvement includes fever rupture. Timepoint: Since admission to the hospital then daily monitoring. Method of measurement: Physical examination, thermometer, questionnaire.;Clinical improvement includes SPO2 >93%. Timepoint: Since admission to the hospital then daily monitoring. Method of measurement: Physical examination, pulse oxymetery,questionnaire.;Improvement of respiratory symptoms. Timepoint: Since admission to the hospital then daily monitoring. Method of measurement: Physical examination, ct scan,questionnaire.;Adverse effects. Timepoint: Since admission to the hospital then daily monitoring. Method of measurement: Questionnaire, physical examination.
Secondary Outcome Measures
NameTimeMethod
Duration of hospitalization. Timepoint: 7 days to 1 months after beginning the treatment. Method of measurement: Questionnaire.;Clinical outcome. Timepoint: 7 days to 1 months after beginning the treatment. Method of measurement: Questionnaire.;Lipoxin. Timepoint: day-0, day-2, day-4. Method of measurement: measuring the plasma concentration of the biomarker with ELISA kit.;Prostaglandin. Timepoint: day-0, day-2, day-4. Method of measurement: measuring the plasma concentration of the biomarker with ELISA kit.;Leukotriene. Timepoint: day-0, day-2, day-4. Method of measurement: measuring the plasma concentration of the biomarker with ELISA kit.;Resolvin. Timepoint: day-0, day-2, day-4. Method of measurement: measuring the plasma concentration of the biomarker with ELISA kit.
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