Feasibility of prescribing non-steroidal anti-inflammatory drugs following surgical repair of long bone fracture healing: A placebo-controlled pilot RCT

Monash University0 个研究点目标入组 40 人开始时间: 2019年10月9日最近更新: 2019年10月14日

试验速览

暂无简介。

•Participants will be eligible if they meet the following inclusion criteria:
•- at least one tibial or femoral shaft fracture managed with either intramedullary nailing or plating
•- an acute hospital length of stay>24 hours at The Alfred Hospital
•- aged 18-65 years.

•Participants will be excluded if they present with:
•- a pathological fracture related to metastatic disease, severe traumatic brain injury and/or spinal cord injury (recovery trajectory varies significantly from the majority of participants)
•- less than conversational-level English (inability to engage in interviewing)
•- multiple major fractures (bilateral tibia and/or femur; unilateral tibia and femur)
•- a Glomerular Filtration Rate (GFR) below 60 mL/ min/1.73m2 or any contraindications to NSAID use (for example: known hypersensitivity including asthma/urticarial/allergic type reactions, allergy to sulphonamides, unstable ischaemic heart disease or thrombus or myocardial infarction or stroke within 3 months, active peptic ulceration or gastrointestinal bleeding, congestive heart failure NYHA II-IV, severe hepatic impairment – (Child-Pugh score greater or equal to 10).
•- opioid and benzodiazepine addiction or opioid tolerance, and other regular illicit drug use or problematic alcohol use

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