Online Assistance for Stent Thrombosis
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 5,000
- 试验地点
- 1
- 主要终点
- Urgent Revascularization
研究概览
简要总结
ONASSIST is a registry of coronary ill patients who have had a functional test measuring anti-platelet effect and/or a genetic profile of response to anti-platelet drugs.
详细描述
The Onassist Project is an assistance for cardiologists that establishes an individual risk of stent thrombosis for each patient based on:
- a functional approach (evaluation of the antiplatelet effect of the antiplatelet regimen by multiple tests) and
- a pharmacogenomic approach (genetic profile of response to antiplatelet agents) It provides advices for specific therapeutics after identification of adverse drug interactions, treatment compliance issues and true genetic, functional or mixed resistance.
This individualized strategy allow to adjust the choice of the drugs and their optimal dosage considering the best benefit - risk ratio.
Follow up are regularly made to identify markers of MACE (major adverse cardiac event) or bleeding.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •coronary disease
- •antiplatelets testing performed as part of usual care and / or gentic profile of antiplatelet response done
排除标准
- •patient refusing to be part of the registry
结局指标
主要结局
Urgent Revascularization
时间窗: 10 years
Death
时间窗: 10 years
Stroke
时间窗: 10 years
Bleeding
时间窗: 10 years
all bleeding according to the BARC (Bleeding Academic Research Consortium) definitions are registered during the follow up
Myocardial Infarction
时间窗: 10 years
Resuscitated Cardiac Arrest
时间窗: 10 years
次要结局
未报告次要终点