A Study of the Individualized Walking Exercise Program on Memory, Subjective Cognitive Complaint, and Brain-derived Neurotrophic Factor Among Postmenopausal Hypertensive Women
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 66
- 试验地点
- 1
- 主要终点
- Memory Function
研究概览
简要总结
The purpose of this study is to determine the effect of 6-month aerobic walking program on memory, subjective cognitive complaints, and brain-derived neurotrophic factor for older hypertensive women. Participants will be randomly assigned to the experimental group and the control group. The intervention group will last for 24 weeks. The outcome measurements included memory, subjective cognitive complaints, and brain-derived neurotrophic factor.
详细描述
The purpose of this study is to explore an aerobic walking program on memory, subjective cognitive complaints, and brain-derived neurotrophic factor. In quantitative study with experimental design, qualified subjects will be randomly assigned to experimental or control group. Experimental subjects will perform six-month aerobic walking program and control group receive routine care. The outcome measurements included memory, subjective cognitive complaints, and brain-derived neurotrophic factor. Data will be collected at baseline, the end of the six-month intervention. Data will be analyzed using Generalized Estimation Equation evaluate the effect of the intervention program.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 60 Years 至 80 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •aged 60-80 years old,
- •a diagnosed of hypertension ≥ 6 months
- •self-reporting the signs of memory or thinking skills problems
排除标准
- •probable cognitive impairment as assessed by Montreal Cognitive Assessment ( < 24 points),
- •significant conditions limiting walking ability (e.g. musculoskeletal problems, visual impairment, etc.),
- •already participating in 30 minutes or more of moderate-intensity exercise five times a week
- •a history of severe cardiovascular disease,
- •a history of neurologic or psychiatric disorder such as stroke, head injury dementia, Parkinson disease, and depression.
研究组 & 干预措施
Aerobic exercise
Behavioral: walking exercise
- The intervention was 24 weeks walking intervention program with moderate-intensity, 5 sessions a week for 30 minutes per section
- individualized education
- telephone and social media counselling
- booklet guidance
干预措施: Aerobic exercise (Behavioral)
control group
Given routine care and life health manual for the participants.
干预措施: control group (Behavioral)
结局指标
主要结局
Memory Function
时间窗: outcome measure at 24th week
The Hopkins Verbal Learning Test was administered to measure verbal learning and memory. The score is a sum of correct responses in each of three learning trial (encoding) (possible score 0 to 36 for summed recall of trials) and a delayed recall trial (possible score 0 to 12). Higher scores mean a better memory.
次要结局
- Subjective Cognitive Complaints(outcome measure at 24th week)
- Brain-derived Neurotrophic Factor(outcome measure at 24th week)