Assessing Fluid-responsiveness Using Non-invasive Hybrid Diffuse Optics on Peripheral Muscle
Overview
- Phase
- Not Applicable
- Status
- Recruiting
- Sponsor
- Corporacion Parc Tauli
- Enrollment
- 200
- Locations
- 1
- Primary Endpoint
- CO Response
Overview
Brief Summary
Proof-of-concept observational study including ICU patients undergoing a PLR maneuver. Local microvasculature will be assessed with the hDOS platform on the brachioradialis muscle, deriving the microvascular blood flow index (BFI) and tissue oxygen saturation (StO2). CO will be assessed via an invasive hemodynamic monitor based on pulse waveform analysis through the patient's arterial line. The correlation over time between CO and microvascular parameters, and the ability of microvascular variables for predicting a positive CO response (increase > 10%) will be assessed.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Invasive blood pressure monitoring through an arterial line
Exclusion Criteria
- •Patients with suspected pregnancy
- •Intra-abdominal hypertension
- •Elevated intracranial pressure
Arms & Interventions
Critical care patient
Critical care patients with their blood pressure invasively monitored through an arterial line
Intervention: Passive Leg Raising maneuver (Other)
Outcomes
Primary Outcomes
CO Response
Time Frame: During procedure
The relative increase in % of the CO, from baseline during the PLR (at 60-120 seconds within the maneuver), will be calculated. Those subjects with a relative increase equal to or above 10% will be classified as CO-responders to the PLR. On the other hand, if the increase in CO during the PLR is below 10%, subjects will be classified as non-responders.
Cardiac Output Response
Time Frame: During procedure
The relative increase in % of the Cardiac Output (CO), from baseline during the Passive Leg Raising (PLR) test (at 60-120 seconds within the maneuver), will be calculated. Those subjects with a relative increase equal to or above 10% will be classified as CO-responders to the PLR. On the other hand, if the increase in CO during the PLR is below 10%, subjects will be classified as non-responders.
Secondary Outcomes
No secondary outcomes reported
Investigators
Jaume Mesquida
Senior Clinical Researcher
Corporacion Parc Tauli