NCT03998293撤回4 期
Direct Measurement of Proinsulin Clearance in Humans
适应症
干预措施
相关药物
试验速览
- 阶段
- 4 期
- 状态
- 撤回
- 发起方
- Mayo Clinic
- 试验地点
- 1
- 主要终点
- Proinsulin Distribution
研究概览
简要总结
Researchers are trying to determine how quickly proinsulin is cleared from the circulation.
详细描述
proinsulin clearance is necessary to determine the rate of secretion into the circulation
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 25 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Weight-stable, non-diabetic subjects from Biobank participants at Mayo Clinic, Rochester
排除标准
- •Age < 25 or > 65 years (to avoid studying subjects who could have latent type 1 diabetes, or the effects of age extremes in subjects with normal or impaired fasting glucose).
- •HbA1c ≥ 6.5%
- •Use of glucose-lowering agents.
- •For female subjects: positive pregnancy test at the time of enrollment or study
- •History of prior upper abdominal surgery such as adjustable gastric banding, pyloroplasty and vagotomy.
- •Active systemic illness or malignancy.
- •Symptomatic macrovascular or microvascular disease.
- •Hormone replacement therapy >0.625 mg premarin daily
研究组 & 干预措施
proinsulin clearance
Other
all participants will be studied once where somatostatin will be used to block endogenous insulin secretion
干预措施: Somatostatin (Drug)
结局指标
主要结局
Proinsulin Distribution
时间窗: through study completion, each study will take an average of 8 hours
The volume of distribution of proinsulin in a given individual
Proinsulin Clearance
时间窗: through study completion, each study will take an average of 8 hours
The half-life of proinsulin in a given individual
次要结局
未报告次要终点
研究者
研究点 (1)
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