Effects of Autogenic Drainage on Ventilation Inhomogeneity in Patients With Cystic Fibrosis
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Change in Lung Clearance Index
研究概览
简要总结
This study will investigate the effects of a chest physiotherapy manual technique (autogenic drainage) on ventilation inhomogeneity in patients with cystic fibrosis. Lung clearance index (LCI) is the primary outcome
详细描述
This is a cross-over intervention assessing the effect of autogenic drainage on ventilation inhomogeneity in patients with cystic fibrosis.
Electrical impedance tomography and multiple breath nitrogen washout will be performed before, immediatly after and 2h post intervention. Each participant will receive either aerosoltherapy alone or in combination with chest physiotherapy on 2 consecutive days.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 6 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Cystic fibrosis diagnosis
- •FEV1 > 40%
- •Able to sustain 30min of chest physiotherapy
排除标准
- •Presence of Burkoldheria cepacia or non tuberculous mycobacteria
- •Orthopedic, neuromuscular or cardiac disorder likely to impact respiratory system
- •Need for supplemental oxygen
- •Cardiac pacemaker or internal cardiac defibrillator
研究组 & 干预措施
Asl + CPT
Aerosotherapy + Autogenic drainage
干预措施: Autogenic drainage (Other)
Asl + CPT
Aerosotherapy + Autogenic drainage
干预措施: Aerosoltherapy (Drug)
Asl
Aerosoltherapy alone
干预措施: Aerosoltherapy (Drug)
结局指标
主要结局
Change in Lung Clearance Index
时间窗: Up to 2 weeks
LCI will be measured before, immediately after and 2h after the experimental or control conditions as well as before and after an hospitalization.
次要结局
- Impedance variation(Up to 1 hour)