CTRI/2025/07/092047尚未招募不适用
Correlation of Macular Ganglion Cell Complex (GCC) Thickness on Optical Coherence Tomography (OCT) With 24-2C SITA Faster and 10-2 SITA Standard on Humphrey Visual Fields in Glaucoma Suspects – A Cross-Sectional Observational Study.
Centre For Sight Eye Hospital1 个研究点 分布在 1 个国家目标入组 92 人开始时间: 2025年8月15日最近更新:
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 92
- 试验地点
- 1
- 主要终点
- To study the correlation between Macular GCC thickness measured by OCT and visual field sensitivity at the additional central test points in the 24-2C SITA Faster and 10-2 SITA Standard HVF in glaucoma suspects.
研究概览
简要总结
This study aims at assessing and studying structural functional correlation between 24-2C SITA Faster and 10-2 SITA Standard HVF defects and Macular GCC thickness. 24-2C SITA Faster and 10-2 SITA Standard, by targeting central test points, enhances the detection of functional correlates of early structural loss which is GCC thinning on OCT, together improving the diagnostic accuracy in glaucoma suspects, aiding early intervention.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •Age greater than or equal to 18 years to 60 years Best-corrected visual acuity (BCVA) greater than or equal to 6/12 Ocular Hypertension Risk factors for glaucoma suspicion: · Ethnicity: African, Hispanic, or Asian · Family history of glaucoma · Elevated IOP greater than or equal to 21 mmHg · Thin central corneas (less than 530-550µm thickness) · High Myopia · Long term steroid medications · Comorbidities like DM, HTN and Cardiovascular Diseases Open Angles on Gonioscopy 24-2C SITA Faster and 10-2 SITA Standard Humphrey Visual Field tests with: Reliable fields (Fixation losses less than 20 percent, False positives and False negatives less than 15 percent) Optic nerve head changes suspicious of glaucoma: · Increased cup-disc ratio greater than or equal to 0.6:1 · Asymmetrical discs greater than or equal to 0.2 · Neuro Retinal Rim notching and/or thinning · Nasalization of retinal vessels · Disc hemorrhages · Retinal Nerve Fiber Layer Wedge defects.
排除标准
- •· Established Glaucoma cases (early, moderate, advanced, POAG, Normal Tension Glaucoma, Secondary glaucoma due to Pseudo-exfoliation Syndrome or Pigment Dispersion Syndrome, etc.) · Non-glaucomatous optic neuropathies · Co- existing Vitreo-Retinal pathologies: Retinal dystrophies, degeneration and detachments Diabetic retinopathy with macular changes Age-related macular degeneration Epiretinal membrane Associated CRVO, BRVO, CRAO and BRAO · Unreliable visual field tests (fixation losses greater than 20 percent, false positives and false negatives greater than 15 percent) · Media Opacities affecting OCT or HVF test results: Corneal opacity Significant cataract (greater than or equal to NS3) Vitreous hemorrhage Dense posterior capsular opacification · Intraocular inflammation: anterior or posterior uveitis.
结局指标
主要结局
To study the correlation between Macular GCC thickness measured by OCT and visual field sensitivity at the additional central test points in the 24-2C SITA Faster and 10-2 SITA Standard HVF in glaucoma suspects.
时间窗: Baseline
次要结局
- 1.To assess the sensitivity and efficacy of GCC analysis by quantifying macular GCC thickness using OCT in glaucoma suspects.
研究者
Dr Jyoti Yadav
Centre For Sight Eye Hospital
研究点 (1)
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