Extended Work Schedules, Sleep Loss and Health

Not Applicable

Completed

• Conditions: Sleep
• Interventions: Behavioral: Fixed restricted bedtimes; Behavioral: Sleep restriction with circadian misalignment

• Registration Number: NCT00989534
• Lead Sponsor: University of Chicago

Brief Summary

This study aims to determine whether abnormal bodily rhythms contribute to elevate the risk of diabetes, independently of the amount of sleep loss.

Detailed Description

Not available

Study Timeline

• Study Start: 2003-01
• Primary Completion: 2007-12
• Study Completion: 2009-09
• Study First Submitted: 2009-10-01
• Study First Submitted QC: 2009-10-02
• Study First Posted: 2009-10-05
• Status Verified: 2016-09
• Last Update Submitted: 2016-09-29
• Last Update Posted: 2016-10-03

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 49

Inclusion Criteria

• normal healthy men and women between the ages of 21 years and 39 years (inclusive) with normal weight (i.e., body mass index under 28 kg/m2 in men, 27 kg/m2 in women)
• normal findings on clinical examination, normal results on routine laboratory tests, normal EKG, normal glucose tolerance test, negative pregnancy test for women
• no personal history of psychiatric or endocrine illness
• no personal history of sleep disorder, usual total sleep time of at least 7 hours
• only female volunteers with normal ovulatory cycles will be included

Exclusion Criteria

• subjects with irregular life habits (shiftworkers and subjects having traveled across time zones less than one month prior to the beginning of the baseline study)
• subjects taking any medication (including hormonal contraceptive therapy), and smokers are excluded
• subjects with significant sleep apnea (apnea index above 10) or significant arousal-associated periodic leg movements are excluded

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Sleep loss and circadian alignment	Fixed restricted bedtimes	Sleep restriction without circadian misalignment
Sleep loss and circadian misalignment	Sleep restriction with circadian misalignment	-

Trial Locations

Locations (1)

The University of Chicago; 🇺🇸 Chicago, Illinois, United States