Effects of Intranasal Oxytocin on Striatal Functional Connectivity in Healthy Males
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 135
- 试验地点
- 1
- 主要终点
- Striatal functional connectivity alterations after drug administration
研究概览
简要总结
To investigate whether 40 IU of intranasal oxytocin treatment can influence the resting-state functional connectivity in healthy males.
详细描述
In a double-blind, between-subject, placebo controlled design, investigators plan to investigate the effects of oxytocin treatment on resting-state functional connectivity.
Subject will receive either intranasal oxytocin or placebo administration and go through a seven-minute resting-state scan in MRI scanner to test whether oxytocin changes functional connectivity in the brain. Trait anxiety and mood questionnaires will be administered as control variables.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 30 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •healthy subjects without past or current psychiatric or neurological disorders
排除标准
- •with MRI Contraindications
研究组 & 干预措施
Oxytocin
干预措施: Oxytocin (Drug)
Placebo
干预措施: Placebos (Drug)
结局指标
主要结局
Striatal functional connectivity alterations after drug administration
时间窗: 45 minutes after drug administration
fMRI-based resting state connectivity of the striatum will be compared between the oxytocin and the placebo group
次要结局
未报告次要终点
研究者
Benjamin Becker
Professor
University of Electronic Science and Technology of China