Minimum Current for Train-of-four Monitoring

Not Applicable

Completed

• Conditions: Anesthesia Recovery Period; Anesthesia; Neuromuscular Blockade
• Interventions: Device: Train-of-four (TOF)

• Registration Number: NCT04581720
• Lead Sponsor: Ewha Womans University Mokdong Hospital

Brief Summary

Neuromuscular monitoring during general anesthesia is important to make sure adequate muscle relaxation during operation and adequate recovery of muscle power and spontaneous breathing during emergence from general anesthesia. The neuromuscular monitoring is usually using electrical stimulants and the method called train-of-four (TOF) is representative. Because it uses electrical stimulants, the patients could be uncomfortable and feel pain during the monitoring when the patients are conscious. Lowering the current of the stimulants would be helpful in reducing the pain, but there is a concern that the TOF results performed in lower current would be underestimated or inaccurate. Therefore, the investigators want to find the minimal current for TOF monitoring that shows adequate TOF results.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2020-09-27
• Study First Submitted QC: 2020-10-06
• Study First Posted: 2020-10-09
• Study Start: 2020-10-12
• Status Verified: 2021-07
• Primary Completion: 2021-07-06
• Study Completion: 2021-07-06
• Last Update Submitted: 2021-07-08
• Last Update Posted: 2021-07-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 36

Inclusion Criteria

• Age 20-65
• Scheduled for an elective surgery
• ASA physical status 1 or 2

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Exclusion Criteria

• BMI > 25 kg/m2
• Neuromuscular disease
• Decreased renal function
• Neurologic disorder
• Impossible to cooperate or communicate

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Participants	Train-of-four (TOF)	The participants will be applied AMG and EMG on each arm of both arms when they finish routine monitoring before the induction of general anesthesia. After the participants being unconscious, we will find each participant's supramaximal current before injecting the neuromuscular blocking agents. During the operation, when the TOF count reaches 4 again and the height of T1 reaches 50% of baseline, we perform TOF tests using 4 currents (Supramaximal current, 0.7×supramaximal current, 0.5×supramaximal current, 0.3×supramaximal current), three times for respective current to figure out that low current can show the same level of TOF ratio as the supramaximal current. When the operation ends and the T1 reaches 100% of baseline, we perform TOF tests with 4 currents again. In the postanesthesia care unit, we use EMG only and perform TOF tests with 4 currents again. The participants can feel pain by the stimulants during the tests, so if they refuse the tests, we stop the tests and record it.

Primary Outcome Measures

Name	Time	Method
Minimal current for TOF	During the operation, from the height of T1 reaches back to the baseline, to the extubation of tracheal tube when the general anesthesia is over.	The minimal current among the four currents we use which is showing not significantly lower TOF ratio than TOF ratio of supramaximal stimulant.

Trial Locations

Locations (1)

Ewha Womans University Mokdong Hospital; 🇰🇷 Seoul, Korea, Republic of