The significance of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in patients with chronic obstructive pulmonary disease
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 242
- 试验地点
- 1
- 主要终点
- To correlate NLR PLR, Procalcitonin, CRP, clinical outcome
研究概览
简要总结
At present, there have been few articles with varying results on the association of neutrophil to lymphocyte (NLR) ratio and platelet to lymphocyte (PLR) ratio in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) compared to stable COPD patients. NLR and PLR are easily accessible and inexpensive markers that have the potential to assist in the risk stratification of hospitalized AECOPD patients, particularly in resource-limited settings, and improve patient outcomes with timely intervention.
Several studies have shown that NLR levels were higher in patients with AECOPD than in stable-state COPD patients, implying that NLR levels can be used as a marker of acute exacerbation. Levels of PLR were also found to be significantly higher in patients who required mechanical ventilation. It was also seen that mean levels of NLR and PLR among patients admitted to ICU were significantly higher among non-survivors compared to survivors of AECOPD.
The combination of NLR, PLR, and CRP have been shown to increase the prognostic sensitivity. It has been concluded that NLR may be an easily available and inexpensive marker for mortality in patients with AECOPD.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 40.00 Year(s) 至 99.00 Year(s)（—）
- 性别
- All
入选标准
- •CASES- 1) Patients with diagnosis of acute exacerbation of COPD defined as acute worsening of respiratory symptoms such as breathlessness, cough with sputum severe enough requiring hospital admission CONTROLS- 1) Clinically stable COPD patients diagnosed on the basis of GOLD guidelines admitted for other reasons in the medical ward or from the medicine and pulmonary medicine outpatient clinic will be taken as controls.
排除标准
- •Patients with bronchial asthma 2)Patients with bronchiectasis 3)Pulmonary tuberculosis patients 4)Patients on oral steroid treatment 5) Patients with other infective conditions- UTI, sepsis due to other causes etc 6)Patients with other inflammatory conditions-inflammatory arthritis, inflammatory bowel disease 7)Patients with autoimmune conditions- SLE etc 8)Patients with hematological disorders 9)Patients with malignancies 10)Patients with a recent MI/stroke.
结局指标
主要结局
To correlate NLR PLR, Procalcitonin, CRP, clinical outcome
时间窗: at the time of recruitment
次要结局
未报告次要终点