Assessing the Efficacy of Male Wolbachia-infected Mosquito Deployments to Reduce Dengue Incidence in Singapore: a Cluster Randomized Controlled Trial
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 724,428
- Locations
- 1
- Primary Endpoint
- Laboratory-confirmed reported dengue case counts normalized by population size in intervention versus non-intervention clusters
Study Overview
Brief Summary
The study is a cluster-randomised controlled trial set in Singapore, to assess if the deployment of male Wolbachia-infected Aedes aegypti mosquitoes can reduce dengue incidence in intervention clusters.
Detailed Description
The study is designed as a parallel, two-arm, non-blinded cluster-randomised controlled trial to be conducted in high-rise public housing estates in Singapore. The aim is to determine whether large-scale deployment of male Wolbachia-infected Ae. aegypti mosquitoes can significantly reduce dengue incidence in intervention clusters. The investigators will use the cluster-randomised design, with the study area comprising 15 clusters with a total area of 10.9 km2, covering approximately 722,000 residents in 1,700 apartment blocks. Eight clusters will be randomly selected to receive the intervention, while the other seven will serve as non-intervention clusters. Intervention efficacy will be estimated through two primary endpoints: (1) odds ratio of Wolbachia exposure distribution (i.e. probability of living in an intervention cluster) among laboratory-confirmed reported dengue cases compared to test-negative controls, and (2) laboratory-confirmed reported dengue counts normalized by population size in intervention versus non-intervention clusters.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Prevention
- Masking
- None
Eligibility Criteria
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Arms & Interventions
Intervention clusters
Residential areas that receive releases of male Wolbachia-infected Aedes aegypti
Intervention: Biological (Male Wolbachia-infected Aedes aegypti) (Biological)
Outcomes
Primary Outcomes
Laboratory-confirmed reported dengue case counts normalized by population size in intervention versus non-intervention clusters
Time Frame: Up to 3 years
Dengue cases data will be obtained from the national surveillance network of diagnostic laboratories which receive samples for dengue testing.
Odds ratio of Wolbachia exposure distribution among laboratory-confirmed reported dengue cases compared to test-negative controls
Time Frame: Up to 3 years
Dengue cases and dengue test-negative controls data will be obtained from the national surveillance network of diagnostic laboratories which receive samples for dengue testing.
Secondary Outcomes
- Prevalence of Ae. aegypti/Ae. albopictus mosquitoes(Up to 3 years)
- Public Attitudes, Perceptions & Knowledge (APK) of Wolbachia and other vector control interventions(Up to 3 years)
Investigators
Lee Ching Ng
Group Director (Environmental Health Institute)
National Environment Agency, Singapore