Prenatal and Postnatal Ultrasonographic Evaluation of Myelomeningocele to Predict Post-Surgical Outcomes
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- self administered questioner
研究概览
简要总结
Myelomeningocele (MMC), also known as open spina bifida, is a serious congenital condition in which the cord and meninges protrude through the spinal column's defective bony encasement due to a defective closure of the posterior portion of the neural tube between the fourth week of pregnancy.
详细描述
The formation of the defect is influenced by both genetic and environmental factors, while the exact cause is yet unknown. There is currently no effective treatment for this common and debilitating central nervous system (CNS) dysfunction.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 28 Weeks 至 40 Weeks（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Gestational age 3rd trimester, Lesion between T1 and S1, Hindbrain herniation and Normal karyotype
排除标准
- •Multiple gestation pregnancy
- •Other fetal anomalies unrelated to myelomeningocele
- •History of incompetent cervix, Other serious maternal medical conditions
- •Inability to adhere to travel and follow-up requirements
- •Contraindication to surgery and Inability to meet trial psychosocial criteria.
结局指标
主要结局
self administered questioner
时间窗: 12 Months
self administered questioner for yelomeningocele patients scroing range fron 0-40. 0 is for lower and 40 is worse and higher
次要结局
未报告次要终点
研究者
Muhammad Naveed Babur
Principal Investigator
Superior University