Comparison study of the pre emptive of the two dose of dexmedetomidine (bolus and infusion) on post operative pain, nausea and vomiting for laparoscopic cholecystectomy
Phase 1
Recruiting
- Conditions
- Pain, nausea and vomiting.
- Registration Number
- IRCT20101211005362N31
- Lead Sponsor
- Esfahan University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 90
Inclusion Criteria
patient candidate to be operated laparoscopic cholecystectomy
one and two ASA
age between 18 - 65 year
Patient consent to participate in the study
Exclusion Criteria
Drug addiction
History of dexmedetomidine allergy
People with a BMI above 30
Use of sleeping pills and analgesics chronically
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Comparison of the effect of different doses of dexmedetomidine on amount of pain. Timepoint: The first hour of recovery every 15 minutes, then 6 hours later, every two hours, and then 12, 24 and 48 hours later is evaluated. Method of measurement: Pain intensity based on VAS scoring system and severity of nausea and vomiting using PONV system.;Comparing the effect of different doses of dexmedetomidine on nausea severity. Timepoint: The first hour of recovery every 15 minutes, then 6 hours later every two hours, and then 12, 24 and 48 hours later is evaluated. Method of measurement: The severity of nausea is measured using the PONV system.;Comparing the effect of different doses of dexmedetomidine on vomiting severity. Timepoint: The first hour of recovery every 15 minutes, then 6 hours later, every two hours, and then 12, 24 and 48 hours later is evaluated. Method of measurement: The severity of vomiting is measured using the PONV system.
- Secondary Outcome Measures
Name Time Method Blood pressure. Timepoint: The first hour of recovery is evaluated every 15 minutes, then 6 hours later, every two hours, and then 12, 24 and 48 hours later. Method of measurement: Blood pressure is measured using a sphygmomanometer.;Heart beat. Timepoint: The first hour of recovery is evaluated every 15 minutes, then every two hours after 6 hours, and then 12, 24, and 48 hours later. Method of measurement: Heart rate is measured using a pulse oximeter.;Blood oxygen level. Timepoint: The first hour of recovery is evaluated every 15 minutes, then every two hours after 6 hours, and then 12, 24, and 48 hours later. Method of measurement: Blood oxygen is measured using a pulse oximeter.;Amount of drugs. Timepoint: The first hour of recovery is evaluated every 15 minutes, then every two hours after 6 hours, and then 12, 24, and 48 hours later. Method of measurement: Using the volume in cc used.