Brain-imaging and Adolescent Neuroscience Consortium
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 试验地点
- 4
研究概览
简要总结
This is a multi-site study of adolescents 12-21 years-of-age to evaluate the long and shorter-term effect of adolescent alcohol use on the developing brain.
详细描述
The overall specific aims of this study are to: 1) assess the short and long-term consequences of alcohol exposure on brain, cognitive, and emotional/regulatory development during preadolescence and adolescence; 2) determine the effects of timing, dose, and duration of alcohol on brain and cognitive development; 3) assess recovery of neural and behavioral function to determine if the plasticity of the adolescent brain makes it more or less vulnerable to alcohol's acute and chronic effects; 4) understand how other key covariates (e.g., existing or emerging psychopathology, family history of alcoholism, demographics, pubertal development) factor into alcohol's effects on the brain; and 5) identify early neural, cognitive, and affective markers that may predict alcohol abuse and dependence during adolescence and/or adulthood.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 12 Years 至 21 Years(Child, Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •able to read and understand English
- •available for follow-up
- •parental consent/adolescent assent for those 12-17 years
- •consent for those 18-21 years
排除标准
- •Weight > 300 lbs
- •braces or unremovable embedded metal
- •claustrophobia or inability to lie still in MRI machine
- •current or past 12-mos pregnancy (females)
- •requires urgent medical/mental health care
