Brain-imaging and Adolescent Neuroscience Consortium
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Alcohol Abuse
- Sponsor
- Boston Children's Hospital
- Locations
- 4
- Status
- Withdrawn
- Last Updated
- 13 years ago
Overview
Brief Summary
This is a multi-site study of adolescents 12-21 years-of-age to evaluate the long and shorter-term effect of adolescent alcohol use on the developing brain.
Detailed Description
The overall specific aims of this study are to: 1) assess the short and long-term consequences of alcohol exposure on brain, cognitive, and emotional/regulatory development during preadolescence and adolescence; 2) determine the effects of timing, dose, and duration of alcohol on brain and cognitive development; 3) assess recovery of neural and behavioral function to determine if the plasticity of the adolescent brain makes it more or less vulnerable to alcohol's acute and chronic effects; 4) understand how other key covariates (e.g., existing or emerging psychopathology, family history of alcoholism, demographics, pubertal development) factor into alcohol's effects on the brain; and 5) identify early neural, cognitive, and affective markers that may predict alcohol abuse and dependence during adolescence and/or adulthood.
Investigators
Eligibility Criteria
Inclusion Criteria
- •able to read and understand English
- •available for follow-up
- •parental consent/adolescent assent for those 12-17 years
- •consent for those 18-21 years
Exclusion Criteria
- •Weight \> 300 lbs
- •braces or unremovable embedded metal
- •claustrophobia or inability to lie still in MRI machine
- •current or past 12-mos pregnancy (females)
- •requires urgent medical/mental health care
Outcomes
Primary Outcomes
Not specified