Comparison of Desflurane and Sevoflurane Minimal Flow Anesthesia on Recovery Parameters and Anesthetic Depth: a Randomized Prospective Study
Overview
- Phase
- Phase 4
- Intervention
- Not specified
- Conditions
- Anesthesia
- Sponsor
- Ufuk University
- Enrollment
- 130
- Locations
- 1
- Primary Endpoint
- Time until transfer readiness
- Last Updated
- 4 years ago
Overview
Brief Summary
Minimal flow anesthesia has economic and environmental advantages in addition to providing earlier recovery following general anesthesia. There is a paucity of data concerning the effect of minimal flow anesthesia (fresh gas flow <0,5 l/min) on recovery parameters. The primary objective of this study is to compare the recovery parameters of desflurane and sevoflurane in minimal flow anesthesia while the secondary objective is to compare the effect of these agents on anesthetic depth using bispectral index.
Investigators
Baturay Kansu Kazbek
Principal Investigator
Ufuk University
Eligibility Criteria
Inclusion Criteria
- •Ages between 18 and 65
- •Patients undergoing elective surgery under general anesthesia
- •Patients with an American Society of Anesthesiologists Classification I or II
Exclusion Criteria
- •Patient refusal
- •Emergency surgery
- •Patients with a contraindication for minimal flow anesthesia
- •Uncontrolled diabetes mellitus
- •History of serious systemic disease (cardiac, pulmonary, hepatic)
- •Utilization of another analgesic technique such as central or peripheral nerve blocks
Outcomes
Primary Outcomes
Time until transfer readiness
Time Frame: Up to 45 minutes after discontinuation of the volatile anesthetic
Time interval between discontinuation of the volatile anesthetics and Aldrete score reaching 9 or greater
Time until extubation
Time Frame: Up to 10 minutes after discontinuation of the volatile anesthetic
Time interval between discontinuation of the volatile anesthetics and removal of the endotracheal tube
Time until eye opening
Time Frame: Up to 20 minutes after discontinuation of the volatile anesthetic
Time interval between discontinuation of the volatile anesthetics and eye opening with verbal command
Secondary Outcomes
- Anesthetic depth provided by the volatile anesthetic(Change in Bispectral Index values at 5, 10, 15, 30, 60 and 120 minutes)