Comparison of Desflurane and Sevoflurane Minimal Flow Anesthesia on Recovery Parameters and Anesthetic Depth: a Randomized Prospective Study
试验速览
- 阶段
- 4 期
- 发起方
- 入组人数
- 130
- 试验地点
- 2
- 主要终点
- Time until transfer readiness
研究概览
简要总结
Minimal flow anesthesia has economic and environmental advantages in addition to providing earlier recovery following general anesthesia. There is a paucity of data concerning the effect of minimal flow anesthesia (fresh gas flow <0,5 l/min) on recovery parameters. The primary objective of this study is to compare the recovery parameters of desflurane and sevoflurane in minimal flow anesthesia while the secondary objective is to compare the effect of these agents on anesthetic depth using bispectral index.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Ages between 18 and 65
- •Patients undergoing elective surgery under general anesthesia
- •Patients with an American Society of Anesthesiologists Classification I or II
排除标准
- •Patient refusal
- •Emergency surgery
- •Patients with a contraindication for minimal flow anesthesia
- •Uncontrolled diabetes mellitus
- •History of serious systemic disease (cardiac, pulmonary, hepatic)
- •Utilization of another analgesic technique such as central or peripheral nerve blocks
结局指标
主要结局
Time until transfer readiness
时间窗: Up to 45 minutes after discontinuation of the volatile anesthetic
Time interval between discontinuation of the volatile anesthetics and Aldrete score reaching 9 or greater
Time until extubation
时间窗: Up to 10 minutes after discontinuation of the volatile anesthetic
Time interval between discontinuation of the volatile anesthetics and removal of the endotracheal tube
Time until eye opening
时间窗: Up to 20 minutes after discontinuation of the volatile anesthetic
Time interval between discontinuation of the volatile anesthetics and eye opening with verbal command
次要结局
- Anesthetic depth provided by the volatile anesthetic(Change in Bispectral Index values at 5, 10, 15, 30, 60 and 120 minutes)
研究者
Baturay Kansu Kazbek
Principal Investigator
Ufuk University