NCT04345887已完成不适用
The Effect of Spironolactone on Oxygenation in Covid-19 ARDS Patients
Istanbul University - Cerrahpasa (IUC)1 个研究点 分布在 1 个国家目标入组 60 人开始时间: 2020年5月5日最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- p/f ratio
研究概览
简要总结
This study intended to evaluate the effects of commonly used diuretic, spironolactone, on oxygenation in covid-19 ARDS patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Hemodynamically stable
- •Hypoxemia, i.e. p/f <150
- •Admitted to ICU within 48 hours
- •Not moribund has a life expectancy greater than 24 hours
排除标准
- •Age criteria
- •Pregnancy
- •Unwillingness to participate
研究组 & 干预措施
Spironolactone
2 x 100 mg spironolactone
干预措施: Spironolactone 100mg (Drug)
Placebo
2 x 1 placebo
干预措施: Placebo oral tablet (Drug)
结局指标
主要结局
p/f ratio
时间窗: 5 days
improvement in oxygenation
次要结局
- SOFA(5 days)
研究者
Olcay Dilken
Dr.
Istanbul University - Cerrahpasa (IUC)
研究点 (1)
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