TO EVALUATE THE EFFICACY OF TRANEXAMIC ACID(drug used to reduce blood loss in various surgeries) IN REDUCING PERIOPERATIVE BLOOD LOSS AND ITS EFFECT ON SHUNT PATENCY IN LIENO RENAL SHUNT SURGERIES (a type of surgery done to reduce the pressure in veins connecting liver and intestine)
- Conditions
- Health Condition 1: null- Patients scheduled for Lieno Renal Shunt surgeries
- Registration Number
- CTRI/2011/08/001940
- Lead Sponsor
- Suryakumar Narayanasamy
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 32
Patients scheduled for LR Shunt surgeries were included in the study if they were more than 18 years of age and less than 65 years of age, ASA physical status ? I-III.
1Bleeding diathesis / dyscrasias (hematopoietic malignancies) or any drug altering coagulation status like antiplatelet drugs (aspirin), warfarin, on NonSteroidal Anti Inflammatory Drugs (NSAIDs) prior to surgery
2Deranged Coagulation parameters
3Patients with renal disorder
4Chronic liver disease (Child B or higher degree) including cirrhotic liver disease
5Ophthalmic problem (retinal involvement)
6History of thromboembolic events (acute coronary syndrome, Cerebro Vascular Accidents [CVA], deep vein thrombosis)
7Pregnancy
8Sepsis
9H/o seizures/epilepsy
10Allergy to Tranexamic acid and
11Patient refusal
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Total Bleeding - intraoperative, postoperative at 6 hours, 24 hours, till removal of drains.Timepoint: intraoperative,postoperative at 6 hours, 24 hours (by total blood in all drains), till removal of drains.
- Secondary Outcome Measures
Name Time Method D-dimer, Fibrinogen, PT, aPTTTimepoint: at preoperative, intraoperatively at 2 hours and postoperatively at 24 hours.;Doppler study for assessing leinorenal shunt patencyTimepoint: at 24 hours and 3 months;Total PRBC, PRP, FFP, plasma transfusedTimepoint: intraoperatively, postoperatively in 24 hours, till removal of drains