SARS-CoV-2 Longitudinal Study: Understanding Susceptibility, Transmission and Disease Severity
Trial Snapshot
- Phase
- Not Applicable
- Status
- Recruiting
- Sponsor
- University College, London
- Enrollment
- 6,000
- Locations
- 3
- Primary Endpoint
- SARS-CoV-2 susceptibility in healthcare workers and patients
Study Overview
Brief Summary
The study aims to investigate SARS-CoV-2 susceptibility, transmission and disease severity in healthcare workers and patients.
Residual specimens from an existing collection of samples in viral inactivating buffer and derivatives and serum from the Crick COVID-19 Consortium Testing centre (Cohort A1) and additional biological material collected prospectively (Cohorts A2 and B) will be used for research into SARS-CoV-2 transmission, evolution and immune control. This testing centre is a partnership between UCLH and The Francis Crick Institute to provide COVID 19 RT PCR testing for healthcare workers (HCWs) and patients in London Hospitals and care homes. A third group (Cohort C) of the study will allow for collaborative work with other REC approved research studies that have used the Crick COVID-19 Consortium Testing centre and will involve the use of study samples already collected from each study to be analysed under the SARS-CoV-2 Longitudinal Study end points
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Individuals who have previously provided nasal throat swab samples for SARS-CoV-2 testing at the Crick COVID 19 Consortium Testing centre.
- •≥18 years of age
- •To enrol in the SARS-CoV-2 positive cohort of the study, the participant should have a positive RT qPCR result
- •Employees based at the participating sites including who had their serology and/or swab tested (for recruitment to Cohort B)
- •Participants enrolled in other studies who had their samples processed by using the Crick COVID 19 Consortium Testing centre (for recruitment to Cohort C).
- •Written informed consent (except Cohort A1)
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
SARS-CoV-2 susceptibility in healthcare workers and patients
Time Frame: 24 months
To investigate SARS-CoV-2 susceptibility by examining the number of positive SARS-CoV-2 result per participant
SARS-CoV-2 transmission in healthcare workers and patients
Time Frame: 24 months
To investigate SARS-CoV-2 transmission by analysis of samples sequencing data from each study centre and across study centres
SARS-CoV-2 severity in healthcare workers and patients
Time Frame: 24 months
To investigate SARS-CoV-2 severity by review of any hospital admissions
Secondary Outcomes
No secondary outcomes reported