A Maintenance Study of Mirikizumab in Participants With Moderately to Severely Active Ulcerative Colitis
- Conditions
- Ulcerative Colitis
- Interventions
- Registration Number
- NCT03524092
- Lead Sponsor
- Eli Lilly and Company
- Brief Summary
The purpose of this study is to evaluate the efficacy and safety of mirikizumab as maintenance therapy in participants who completed as clinical responders in the prior 12-week induction study LUCENT-1 (NCT03518086).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 1177
- Have completed Study AMAN (NCT03518086), with at least 1 study drug administration and without early termination of study drug.
- Are willing and able to complete the scheduled study assessments, including endoscopy and daily diary entry.
- If female, must meet the contraception requirements.
- Participants diagnosed with Crohn's disease or inflammatory bowel disease-unclassified (indeterminate colitis) during the induction study AMAN (NCT03518086).
- Participants with a bowel resection or other surgery for the treatment of UC during the previous induction study AMAN (NCT03518086), or are likely to require surgery for the treatment of UC during study AMBG.
- Participants with evidence of colonic dysplasia or have been diagnosed with cancer of the gastrointestinal tract during study AMAN (NCT03518086).
- Participants diagnosed with clinically important infection including, but not limited to, hepatitis B, hepatitis C, HIV/AIDS, and active tuberculosis (TB) during the induction study AMAN (NCT03518086).
- Participants who initiate a new prohibited medication during the induction study AMAN (NCT03518086).
- Participants with certain laboratory abnormalities prior to start of AMBG that would require permanent discontinuation from study drug.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Open Label Maintenance: Delayed Responders - 200 mg Miri SC Mirikizumab SC Participants who initially did not respond to induction study (LUCENT-1), but responded to extended induction therapy at Week 12 of LUCENT-2 (delayed responders), received 200 mg mirikizumab SC Q4W during open label maintenance period from Week 12 until Week 40. Extended Induction: Induction Nonresponders - 300mg Miri IV Mirikizumab IV Participants who were nonresponders to blinded mirikizumab or placebo in induction study (LUCENT-1), received additional 3 doses of open label 300 mg mirikizumab IV Q4W during extended induction period from Week 0 of LUCENT-2 until Week 12. Loss of Response (LOR) Rescue Period:LOR Cohort-300 mg Miri IV Mirikizumab IV Participants who received PBO SC or 200 mg mirikizumab SC Q4W during maintenance period and experienced a loss of response at or after Week 12, received rescue therapy with open label 300 mg mirikizumab intravenous (IV) Q4W for 3 doses. Maintenance Period: Miri IR - 200 Milligram (mg) Miri SC Mirikizumab SC Participants who were responders to blinded mirikizumab at Week 12 in induction study (LUCENT-1) randomized to continue to receive 200 mg mirikizumab SC Q4W from Week 0 of LUCENT-2 until Week 40 or until loss of response was confirmed. Maintenance Period: Miri Induction Responder (IR) - Placebo (PBO) Subcutaneous (SC) Placebo SC Participants who were responders to blinded mirikizumab (miri) at Week 12 in induction study (LUCENT-1) randomized to withdraw from mirikizumab and start receiving PBO SC every 4 weeks (Q4W) from Week 0 of maintenance study (LUCENT-2) until Week 40 or until loss of response was confirmed. Maintenance Period: PBO IR - PBO SC Placebo SC Participants who were responders to blinded placebo at Week 12 in induction study (LUCENT-1) continue to receive blinded placebo SC Q4W from Week 0 of LUCENT-2 until Week 40 or until loss of response was confirmed.
- Primary Outcome Measures
Name Time Method Percentage of Participants in Clinical Remission at Week 40 Week 40 Clinical remission at week 40 is defined as achieving a 9-point modified Mayo score for rectal bleeding=0, stool frequency=0 or 1 with ≥ 1 point decrease from baseline, and endoscopy=0 or 1 (excluding friability).
Stool Frequency Subscore, based on the participant's diary and scored from 0 (normal number of stools) to 3 (5 or more stools than normal); Rectal Bleeding Subscore, based on the participant's diary and scored from 0 (no blood) to 3 (blood only passed); Endoscopy Subscore, based on central reading of colonoscopy or sigmoidoscopy and scored from 0 (normal or inactive disease) to 3 (severe disease, spontaneous bleeding, ulceration).
- Secondary Outcome Measures
Name Time Method Percentage of Participants With Histologic Remission at Week 40 Week 40 Histologic remission was assessed using the Geboes histologic scoring system developed for assessment of histologic disease activity in ulcerative colitis. Remission was defined as Geboes histological subscore of 0 for grades: 2b (lamina propria neutrophils), and 3 (neutrophils in epithelium), and 4 (crypt destruction), and 5 (erosion or ulceration).
Percentage of Participants in Symptomatic Remission at Week 40 Week 40 Symptomatic remission at week 40 is defined as a Mayo score for rectal bleeding=0, stool frequency=0 or 1 with ≥ 1 point decrease from baseline.
Stool frequency subscore, based on the participant's diary and scored from 0 (normal number of stools) to 3 (5 or more stools than normal).
Rectal bleeding subscore, based on the participant's diary and scored from 0 (no blood seen) to 3 (blood alone passed).Percentage of Participants in Endoscopic Response at Week 40 Week 40 Endoscopic response at week 40 is defined as achieving at least a 1 point decrease from baseline in the Mayo endoscopic subscore.
Percentage of Participants in Endoscopic Remission at Week 40 Week 40 Endoscopic remission at week 40 is defined as achieving a Mayo endoscopic subscore of 0 or 1 (excluding friability) at Week 40. Endoscopy subscore is based on colonoscopy or sigmoidoscopy and scored from 0 (normal or inactive disease) to 3 (severe disease, spontaneous bleeding, ulceration).
Change From Baseline to Week 40 in Health Related Quality of Life: Inflammatory Bowel Disease Questionnaire (IBDQ) Total Score Induction Baseline, Week 40 The IBDQ is a 32-item participant-completed questionnaire that measures 4 aspects of subjects' lives: symptoms directly related to the primary bowel disturbance, systemic symptoms, emotional function, and social function. Responses are graded on a 7-point. Likert scale in which 7 denotes "not a problem at all" and 1 denotes "a very severe problem." Scores range from 32 to 224; a higher score indicates a better quality of life. Least square (LS) Mean was calculated using analysis of covariance (ANCOVA) model for post-baseline measures: The ANCOVA model includes: treatment, baseline value, prior biologic or tofacitinib failure (yes/no), clinical remission status (yes/no) at AMAN Week 12, and region (North America/Europe/Other).
Change From Baseline to Week 40 in Fecal Calprotectin Induction Baseline, Week 40 Fecal calprotectin is an indicator of inflammation in the colon with higher levels indicative of higher levels of inflammation. Least square (LS) Mean was calculated using ANCOVA model for post-baseline measures: The ANCOVA model includes treatment, baseline value, prior biologic or tofacitinib failure (yes/no), corticosteroid use (yes/no) at AMAN baseline, region (North America/Europe/Other), Clinical Remission status (yes/no) at AMAN Week 12.
Change From Baseline to Week 40 in Bowel Urgency Based on the Urgency Numeric Rating Scale (NRS) Induction Baseline, Week 40 The Urgency NRS is a single participant reported item that measures the severity for the urgency (sudden or immediate need) to have a bowel movement in the past 24 hours using an 11-point NRS ranging from 0 (no urgency) to 10 (worst possible urgency). Higher scores indicate more severe urgency. Least square (LS) Mean was calculated using mixed model repeated measures (MMRM) model for post-baseline measures: The MMRM model includes treatment, baseline value, visit, interaction of baseline value-by-visit, interaction of treatment-by-visit, prior biologic or tofacitinib failure (yes/no), baseline corticosteroid use (yes/no), clinical remission status (yes/no) at AMAN Week 12, and region (North America/Europe/Other).
Percentage of Participants in Clinical Response at Week 40 Week 40 Clinical response at week 40 is defined as a decrease in the 9-point modified Mayo score (MMS) \[rectal bleeding, stool frequency and the endoscopic findings\] inclusive of \>= 2 points and \>=30% from baseline with either a decrease of rectal bleeding subscore of \>=1 or rectal bleeding subscore of 0 or 1.The MMS is a composite score of ulcerative colitis disease activity calculated as the sum of three subscores: Stool frequency subscore, based on the participant's diary and scored from 0 (normal number of stools) to 3 (5 or more stools than normal); Rectal bleeding subscore, based on the participant's diary and scored from 0 (no blood seen) to 3 (blood alone passed); Endoscopy subscore, based on colonoscopy or sigmoidoscopy and scored from 0 (normal or inactive disease) to 3 (severe disease, spontaneous bleeding,ulceration).
Percentage of Participants Hospitalized for Ulcerative Colitis (UC) Week 40 Percentage of participants hospitalized for UC. Only hospitalizations associated with an adverse event with \>=24 hours stay were recorded.
Pharmacokinetics (PK): Clearance of Mirikizumab Predose: Weeks 0, 4, 12, 24 and 40 Clearance of mirikizumab was evaluated.
Trial Locations
- Locations (383)
Physicians Research Group
🇺🇸Tempe, Arizona, United States
SIH Research, LLC
🇺🇸Kissimmee, Florida, United States
Care Access Research
🇺🇸Berkeley, California, United States
Wellness Clinical Research
🇺🇸Miami Lakes, Florida, United States
Om Research, LLC
🇺🇸Lancaster, California, United States
Care Access Research LLC
🇺🇸Jackson, Mississippi, United States
Digestive Health Specialists
🇺🇸Tupelo, Mississippi, United States
Northwell Health
🇺🇸Great Neck, New York, United States
Digestive Healthcare of Georgia
🇺🇸Atlanta, Georgia, United States
Central Sooner Research
🇺🇸Norman, Oklahoma, United States
Houston Methodist Research Ins
🇺🇸Houston, Texas, United States
Biopharma Informatic, LLC
🇺🇸Houston, Texas, United States
Research Associates of South Florida, LLC
🇺🇸Miami, Florida, United States
Indiana University School of Medicine
🇺🇸Indianapolis, Indiana, United States
Clinical Applications Laboratories, Inc.
🇺🇸San Diego, California, United States
Maricopa Integrated Health System
🇺🇸Phoenix, Arizona, United States
University of Oklahoma Health Sciences Center
🇺🇸Oklahoma City, Oklahoma, United States
UCSF Medical Center at Mission Bay
🇺🇸San Francisco, California, United States
Gastroenterology Research of San Antonio
🇺🇸San Antonio, Texas, United States
Southern Star Research Institute, LLC
🇺🇸San Antonio, Texas, United States
Wisconsin Center for Advanced Research
🇺🇸Milwaukee, Wisconsin, United States
Hospital Gen. Juan Ramon Jimenez - Depto de Digestivo
🇪🇸Sagunto, Valencia, Spain
Digestive Health Specialists of the Southeast
🇺🇸Dothan, Alabama, United States
Valley Gastroenterology
🇺🇸Arcadia, California, United States
Dcr-Pi, Pc
🇺🇸Litchfield Park, Arizona, United States
Direct Helpers Research Center
🇺🇸Hialeah, Florida, United States
California Medical Research Associates
🇺🇸Northridge, California, United States
Nature Coast Clinical Research, LLC
🇺🇸Inverness, Florida, United States
Grand Teton Research Group
🇺🇸Idaho Falls, Idaho, United States
Gastroenterology Associates of Pensacola, PA
🇺🇸Pensacola, Florida, United States
Florida Medical Clinic LLC
🇺🇸Zephyrhills, Florida, United States
NorthShore University HealthSystem
🇺🇸Evanston, Illinois, United States
Cotton-O'Neil Clinical Research Center, Digestive Health
🇺🇸Topeka, Kansas, United States
Texas Digestive Disease Consultants
🇺🇸Southlake, Texas, United States
Delta Research Partners LLC
🇺🇸Monroe, Louisiana, United States
Henry Ford Health System
🇺🇸Novi, Michigan, United States
Gastroenterology Associates of Western Michigan, P.L.C.
🇺🇸Wyoming, Michigan, United States
Huron Gastroenterology Associates
🇺🇸Ypsilanti, Michigan, United States
MNGI Digestive Health - Plymouth Endoscopy Center & Clinic
🇺🇸Plymouth, Minnesota, United States
Clinical Research Institute of Michigan, LLC
🇺🇸Chesterfield, Michigan, United States
Carolina Digestive Diseases and Endoscopy Center
🇺🇸Greenville, North Carolina, United States
Paramount Medical Research
🇺🇸Middleburg Heights, Ohio, United States
Care Access - Youngstown
🇺🇸Poland, Ohio, United States
Digestive Disease Associates
🇺🇸Wyomissing, Pennsylvania, United States
Midwest Medical Care
🇺🇸Sioux Falls, South Dakota, United States
Galen Medical Group
🇺🇸Hixson, Tennessee, United States
Gastro One
🇺🇸Germantown, Tennessee, United States
Digestive Health Associates of Texas
🇺🇸Garland, Texas, United States
Care Access Research LLC - Salt Lake City
🇺🇸Ogden, Utah, United States
Emeritas Research Group
🇺🇸Leesburg, Virginia, United States
The Gastroenterology Group, P.C.
🇺🇸Reston, Virginia, United States
Centro de Investigaciones Metabólicas (CINME)
🇦🇷Caba, Buenos Aires, Argentina
Mautalen Salud e Investigacion-Centro de Osteopatías Médicas
🇦🇷Ciudad Autonoma De Buenos Air, Buenos Aires, Argentina
CER Instituto Medico
🇦🇷Quilmes, Buenos Aires, Argentina
Fundación de Estudios Clínicos
🇦🇷Rosario, Santa Fe, Argentina
Centro de Investigaciones Médicas Tucuman
🇦🇷SAN M. DE Tucuman, Tucumán, Argentina
C.I.C.E. 9 de Julio
🇦🇷San Miguel de Tucumán, Tucumán, Argentina
Hospital Privado Centro Medico de Cordoba SA
🇦🇷Cordoba, Argentina
Princess Alexandra Hospital
🇦🇺Harlow, Essex, Australia
Royal Adelaide Hospital
🇦🇺Adelaide, South Australia, Australia
Coastal Digestive Health
🇦🇺Maroochydore, Queensland, Australia
Mater University Hospital
🇦🇺South Brisbane, Queensland, Australia
Box Hill Hospital Outpatients
🇦🇺Box Hill, Victoria, Australia
The Alfred Hospital
🇦🇺Melbourne, Victoria, Australia
Melbourne Gastrointestinal Investigation Unit (MGIU)
🇦🇺Malvern, Victoria, Australia
The Royal Melbourne Hospital
🇦🇺Parkville, Victoria, Australia
Universitätsklinikum Salzburg
🇦🇹Salzburg, Austria
Medical University of Vienna
🇦🇹Vienna, Austria
Universitair Ziekenhuis Gent
🇧🇪Gent, Oost-Vlaanderen, Belgium
Centre Hospitalier de Wallonie Picarde - Site Notre Dame
🇧🇪Tournai, Wallonne, Région, Belgium
PerCuro Clinical Research
🇨🇦Victoria, British Columbia, Canada
ISCARE Clinical Centre
🇨🇿Praha 9, Czechia
The Gordon and Leslie Diamond Health Care Centre
🇨🇦Vancouver, British Columbia, Canada
GI Research Institute
🇨🇦Vancouver, British Columbia, Canada
Victoria Hospital
🇨🇦London, Ontario, Canada
AZ Klina
🇧🇪Brasschaat, Belgium
Universitaire Ziekenhuizen Leuven - Campus Gasthuisberg
🇧🇪Leuven, Belgium
University of Western Ontario
🇨🇦London, Ontario, Canada
Centre de santé et de services sociaux Champlain-Charles-Le Moyne
🇨🇦Greenfield Park, Quebec, Canada
Hopital Maisonneure-Rosemount
🇨🇦Montreal, Quebec, Canada
Inflammatory Bowel Disease Centre Montreal General Hospital - MUHC
🇨🇦Montreal, Quebec, Canada
Anhui Provincial Hospital
🇨🇳Hefei City, Anhui, China
The First Affiliated Hospital of Anhui Medical University
🇨🇳Hefei City, Anhui, China
Xiangya Hospital Central South University
🇨🇳Kaifu District, Changsha City, China
The Affiliated 2nd Hosp. of Third Military Med. Univ. of PLA
🇨🇳Chongqing, Chongqing, China
Union Hospital Tongji Medical College Huazhong University of Science and Technology
🇨🇳Wuhan, Hubei, China
Renmin Hospital of Wuhan University
🇨🇳Wuhan, Hubei, China
The Sixth Affiliated Hospital, Sun Yat-Sen University
🇨🇳Guangzhou, Guangdong, China
The First Hospital Affiliated to AMU (Southwest Hospital)
🇨🇳Chongqing, Chongqing, China
The Affiliated Drum Tower Hospital of Nanjing University
🇨🇳Nanjing, Jiangsu, China
Zhongda Hospital Southeast University
🇨🇳Nanjing, Jiangsu, China
Nanjing Medical University - Nanjing Jiangning Hospital
🇨🇳Nanjing, Jiangsu, China
Jiangxi Pingxiang People's Hospital
🇨🇳Pingxiang, Jiangxi, China
The Affiliated Hospital of Qingdao University
🇨🇳Qingdao, Shandong, China
Jilin Central General Hospital
🇨🇳Jilin, Jilin, China
Qilu Hospital of Shandong University
🇨🇳Jinan, Shandong, China
Shandong Provincial Hospital
🇨🇳Jinan, Shandong, China
Liaocheng People's Hospital
🇨🇳Liaocheng, Shandong, China
Taian City Central Hospital
🇨🇳Taian, Shandong, China
Shanghai Jiaotong University School of Medicine Ruijin Hospital
🇨🇳Shanghai, Shanghai, China
Renji Hospital Affliated to Shanghai Jiaotong University
🇨🇳Shanghai, Shanghai, China
West China Hospital, Sichuan University
🇨🇳Chengdu, Sichuan, China
Kunming Medical College Affiliated First Hospital
🇨🇳Kunming, Yunnan, China
The First People's Hospital of Yunnan Province
🇨🇳Kunming, Yunnan, China
The Second Affiliated Hospital of Zhejiang University School of Med
🇨🇳Hangzhou, Zhejiang, China
First Affiliated Hosp of College of Med, Zhejiang University
🇨🇳Hangzhou, Zhejiang, China
Sir Run Run Shaw Hospital
🇨🇳Hangzhou, Zhejiang, China
The Second Affiliated Hospital YuYing Childens Hospital of Wenzhou Medical university
🇨🇳Wenzhou, Zhejiang, China
MEDIENDO
🇨🇿Prague, Praha 8, Czechia
Zealand University Hospital Køge
🇩🇰Køge, Denmark
Tongji Hospital of Tongji University
🇨🇳Wuhan, China
MUDr. Gregar, s.r.o.
🇨🇿Olomouc, Olomoucký Kraj, Czechia
A-Shine
🇨🇿Pilsen, Plzeň-město, Czechia
Fakultni Nemocnice u sv. Anny v Brne
🇨🇿Brno, Czechia
PreventaMed, s.r.o.
🇨🇿Olomouc, Czechia
Fakultni nemocnice Kralovske Vinohrady
🇨🇿Praha 10, Hl. M. Praha, Czechia
Hepato-Gastroenterologie HK
🇨🇿Hradec Kralove, Hradec Králové, Czechia
Herlev and Gentofte Hospital
🇩🇰Herlev, Denmark
Hopital de Hautepierre - Service d'Hépatogastroentérolgie
🇫🇷Strasbourg Cedex, Bas Rhin, France
Vojenská Nemocnice Brno
🇨🇿Brno, Brno-město, Czechia
Hopital Saint-Louis
🇫🇷Paris, Cedex 10, France
CHU Lille - Hôpital Claude Huriez
🇫🇷Lille cedex, Nord, France
Hôpital Beaujon
🇫🇷Clichy, Paris, France
Centre Hospitalier de Pau
🇫🇷Pau, Pyrénées-Atlantiques, France
Hospices Civils de Lyon - Centre Hospitalier Lyon Sud -
🇫🇷Pierre Benite cedex, Rhone, France
CHU Amiens Picardie-Site Sud - RDC Service Hépato gastro
🇫🇷Amiens Cedex, Somme, France
CHU Tours - Hôpital Trousseau
🇫🇷Chambray les Tours, France
Assistance Publique Hôpitaux de Marseille - Hôpital Nord
🇫🇷Marseille Cedex 20, France
CHRU de Montpellier-Hopital St Eloi
🇫🇷Montpellier Cedex 5, France
Hopital L'Archet 2
🇫🇷Nice Cedex, France
CHU Bordeaux - Hôpital Haut-Lévêque
🇫🇷Pessac Cedex, France
Robert Debre Hospital
🇫🇷Reims, France
CHRU Nancy Brabois - Hôpital d'Enfants
🇫🇷Vandoeuvre les Nancy, France
CHU de Saint Etienne Hopital Nord
🇫🇷Saint Priest en Jarez, France
Universitätsklinikum Halle
🇩🇪Halle (Saale), Sachsen-Anhalt, Germany
Medizinische Hochschule Hanover
🇩🇪Hannover, Niedersachsen, Germany
Gemeinschaftspraxis Dr. Peter Uebel
🇩🇪Ludwigshafen am Rhein, Rheinland-Pfalz, Germany
Studiengesellschaft BSF Unternehmergesellschaft
🇩🇪Halle (Saale), Sachsen-Anhalt, Germany
HaFCED - Hamburgisches Forschungsinstitut für chronisch entzündliche Darmerkrankungen
🇩🇪Hamburg, Germany
Charité Campus Virchow-Klinikum
🇩🇪Berlin, Germany
Städtisches Klinikum Brandenburg
🇩🇪Brandenburg, Germany
Krankenhaus Waldfriede
🇩🇪Berlin, Germany
Internistische Praxisgemeinschaft
🇩🇪Weyhe, Germany
DRC Gyogyszervizsgalo Kozpont Kft.
🇭🇺Balatonfüred, EU, Hungary
Jávorszky Ödön Kórház
🇭🇺Vác, Pest, Hungary
Óbudai Egészségügyi Centrum
🇭🇺Budapest, Hungary
Debreceni Egyetem Klinikai Kozpont
🇭🇺Debrecen, Hungary
Semmelweis Egyetem
🇭🇺Budapest, Hungary
Karolina Korhaz-Rendelointezet
🇭🇺Mosonmagyarovar, Hungary
Endomedix Diagnosztikai Központ - Miskolc
🇭🇺Miskolc, Hungary
Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont I. Belgyogyaszati Klinika
🇭🇺Szeged, Hungary
CLINFAN Szolgáltató Kft
🇭🇺Szekszard, Hungary
Centre for Liver Research & Diagnostics, Deccan College of Medical Sciences, Owaisi Hospital & Research Centre
🇮🇳Hyderabad, Andhra Pradesh, India
Apollo Research and Innovations, Apollo Hospitals International Ltd
🇮🇳Gandhinagar, Gujarat, India
Escorts Heart Institute and Research Centre Ltd
🇮🇳New Delhi, Delhi, India
Dayanand Medical College and Hospital
🇮🇳Ludhiana, Punjab, India
M S Ramaiah Medical College and Hospitals
🇮🇳Bangalore, Karnataka, India
Shree Giriraj Multispeciality Hospital
🇮🇳Rajkot, Gujarat, India
King George Medical University
🇮🇳Lucknow, Uttar Pradesh, India
Nirmal Hospital Pvt Ltd.
🇮🇳Surat, Gujarat, India
Midas Multispeciality Hospital Pvt.Ltd.
🇮🇳Nagpur, Maharashtra, India
SR Kalla Memorial Gastro & General Hospital
🇮🇳Jaipur, Rajasthan, India
Poona Medical Foundation. Ruby Hall Clinic
🇮🇳Pune, Maharashtra, India
Bangalore Medical College and Research Institute
🇮🇳Bangalore, Karnataka, India
Datta Meghe Institute of Medical Sciences (DU), Acharya Vinoba Bhave Rural Hospital
🇮🇳Wardha, Maharashtra, India
Gandhi Hospital
🇮🇳Hyderabad, Telangana, India
Shaare Zedek Medical Center
🇮🇱Bait Vagan, Jerusalem, Israel
Soroka Medical Center - Pediatric Outpatient Clinic
🇮🇱Beer-Sheva, Israel
Beaumont Hospital, Dublin
🇮🇪Dublin, Ireland
Galilee Medical Center Department of Internal Medicine A
🇮🇱Nahariya, Israel
Kaplan Medical Center
🇮🇱Rehovot, Israel
Tel Aviv Sourasky Medical Center
🇮🇱Tel Aviv, Israel
Presidio di Rho
🇮🇹Rho, Milano, Italy
Istituto Clinico Humanitas
🇮🇹Rozzano, Milano, Italy
Istituti di Ricovero e Cura a Carattere Scientifico Policlinico San Donato Gastroenterologia
🇮🇹San Donato Milanese, Milano, Italy
Ospedale Sandro Pertini
🇮🇹Rome, Roma, Italy
Azienda Ospedaliera Universitaria Policlinico Tor Vergata
🇮🇹Torre, Roma, Italy
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (Presidio Spedali Civili)
🇮🇹Brescia, Italy
Azienda ospedaliero-universitaria Mater Domini
🇮🇹Catanzaro, Italy
Azienda Ospedaliero Universitaria San Martino
🇮🇹Genova, Italy
King Fahad Medical City
🇮🇱Zerifin, Israel
Gastroenterology and Endoscopy Unit IRCCS Ca' Granda Ospedale Maggiore Policlinico Foundation
🇮🇹Milano, Italy
Azienda Ospedaliera Universitaria Policlinico de Modena
🇮🇹Modena, Italy
Azienda Ospedaliera Universitaria Pisana
🇮🇹Pisa, Italy
Fujita Health University
🇯🇵Toyoake, Aichi, Japan
National Hospital Organization Hirosaki National Hospital
🇯🇵Hirosaki, Aomori, Japan
Ospedale Mauriziano Umberto I
🇮🇹Torino, Italy
Azienda Ospedaliero-Universitaria Santa Maria della Misericordia Gastroenterologia
🇮🇹Udine, Italy
Policlinico Gemelli - Università Cattolica del Sacro Cuore
🇮🇹Roma, Italy
Aichi Medical University Hospital
🇯🇵Nagakute-shi, Aichi-ken, Japan
Toho University Sakura Medical Center
🇯🇵Sakura, Chiba, Japan
Kitakyushu Municipal Medical Center
🇯🇵Kitakyusyu-shi, Fukoka, Japan
Hidaka Coloproctology Clinic
🇯🇵Kurume-shi, Fukuoka-Ken, Japan
Fukuoka University Chikushi Hospital
🇯🇵Chikushino, Fukuoka, Japan
Gunma University Hospital
🇯🇵Maebashi, Gunma, Japan
National Hospital Organization Takasaki General Medical Centar
🇯🇵Takasaki, Gunma, Japan
NHO Mito Medical Center
🇯🇵Ibaraki-machi, HigaShiibaraki-Gun, Japan
Asahikawa City Hospital
🇯🇵Asahikawa, Hokkaido, Japan
Tokushukai Sapporo Tokushukai Hospital
🇯🇵Sapporo-shi, Hokkaido, Japan
Hokkaido P.W.F.A.C. Sapporo-Kosei General Hospital
🇯🇵Sapporo-shi, Hokkaido, Japan
Sapporo Higashi Tokushukai Hospital
🇯🇵Sapporo, Hokkaido, Japan
Aoyama Clinic GI Endoscopy & IBD Center
🇯🇵Kobe-shi, Hyogo-Ken, Japan
Kagawa Prefectural Central Hospital
🇯🇵Takamatsu, Kagawa, Japan
Sankikai Yokohama Shin midori General Hospital
🇯🇵Yokohama-shi, Kanagawa-Ken, Japan
Ofuna Central Hospital
🇯🇵Kamakura, Kanagawa, Japan
Showa University Northern Yokohama Hospital
🇯🇵Yokohama, Kanagawa, Japan
Kawasaki Municipal Hospital
🇯🇵Kawasaki, Kanagawa, Japan
Yokohama City University Medical Center
🇯🇵Yokohama, Kanagawa, Japan
Kumamoto University Hospital
🇯🇵Kumamoto-shi, Kumamoto, Japan
Mie University Hospital
🇯🇵Tsu, Mie, Japan
Takagi Clinic - Sendai
🇯🇵Sendai-shi, Miyagi-Ken, Japan
Nagaoka Chuo General Hospital
🇯🇵Nagaoka-shi, Niigata, Japan
Ishida Clinic of IBD and Gastroenterology
🇯🇵Oita-shi, Oita-Ken, Japan
Sai Gastroenterologist Proctology
🇯🇵Fujiidera, Osaka, Japan
Infusion Clinic
🇯🇵Osaka-shi, Osaka, Japan
NHO Osaka National Hospital
🇯🇵Osaka-shi, Osaka, Japan
Saga-Ken Medical Center Koseikan
🇯🇵Saga-Shi, Saga-Ken, Japan
Kumagaya General Hospital
🇯🇵Kumagaya-shi, Saitama-Ken, Japan
Matsuda Hospital
🇯🇵Hamamatsu-shi, Shizuoka-Ken, Japan
Jichi Medical University Hospital
🇯🇵Shimotsuke-shi, Tochigi-Ken, Japan
Kyorin University Hospital
🇯🇵Mitaka, Tokyo, Japan
Mitsui Memorial Hospital
🇯🇵Chiyoda-ku, Tokyo-To, Japan
Center Hospital of the National Center for Global Health and Medicine
🇯🇵Shinjuku-ku, Tokyo-To, Japan
Juntendo University Hospital
🇯🇵Bunkyo-ku, Tokyo, Japan
Tokyo Medical and Dental University Hospital
🇯🇵Bunkyō, Tokyo, Japan
Kitasato University Kitasato Institute Hospital
🇯🇵Minato-Ku, Tokyo, Japan
Showa University Koto Toyosu Hospital
🇯🇵Koto-ku, Tokyo, Japan
JHCO Tokyo Yamate Medical Center
🇯🇵Shinjuku-ku, Tokyo, Japan
National Hospital Organization Kyoto Medical Center
🇯🇵Kyoto, Japan
Okayama University Hospital
🇯🇵Okayama, Japan
Tokitokai Tokito Clinic
🇯🇵Saitama, Japan
Fukuoka University Hospital
🇯🇵Fukuoka, Japan
Hiroshima University Hospital
🇯🇵Hiroshima, Japan
Sameshima Hospital
🇯🇵Kagoshima, Japan
Toyama Prefectural Central Hospital
🇯🇵Toyama, Japan
Severance Hospital, Yonsei University Health System
🇰🇷Wonju-si, Gangwon-do, Korea, Republic of
Dong-A University Hospital
🇰🇷Busan, Pusan-Kwangyǒkshi, Korea, Republic of
Kangbuk Samsung Hospital
🇰🇷Seoul, Seoul-teukbyeolsi [Seoul], Korea, Republic of
Asan Medical Center
🇰🇷Seoul, Seoul-teukbyeolsi [Seoul], Korea, Republic of
Samsung Medical Center
🇰🇷Seoul, Seoul-teukbyeolsi [Seoul], Korea, Republic of
The Catholic University of Korea, Daejeon St. Mary's Hospital
🇰🇷Daejeon, Taejǒn-Kwangyǒkshi, Korea, Republic of
Kyung Hee University Hospital
🇰🇷Seoul, Korea, Korea, Republic of
Inje University Haeundae Paik Hospital
🇰🇷Busan, Korea, Republic of
Pauls Stradins Clinical Univeristy Hospital
🇱🇻Riga, Rīga, Latvia
Yeungnam Univeristy Medical Center
🇰🇷Daegu, Korea, Republic of
Digestive Diseases Center "Gastro"
🇱🇻Riga, Latvia
Riga Eastern Clinical University Hospital
🇱🇻Riga, Latvia
Respublikine Panevezio ligonine
🇱🇹Panevezys, Panevėžio Apskritis, Lithuania
Hospital of Lithuanian University of Health Sciences Kaunas
🇱🇹Kaunas, Lithuania
Republic Hospital of Klaipeda
🇱🇹Klaipeda, Lithuania
Klaipeda Seamen's Hospital
🇱🇹Klaipeda, Lithuania
Vilnius University Hospital Santariskiu Clinics
🇱🇹Vilnius, Lithuania
Hospital Ampang
🇲🇾Ampang, Selangor, Malaysia
Centro Para el Desarrollo de la Medicina y de Asistencia Medica S.C
🇲🇽Culiacan, Sinaloa, Mexico
Universiti Sains Malaysia
🇲🇾Kubang Kerian, Kelantan, Malaysia
University Malaya Medical Centre
🇲🇾Lembah Pantai, Kuala Lumpur, Malaysia
Centro de Investigación Clínica Acelerada
🇲🇽Mexico City, Distrito Federal, Mexico
Investigación Biomédica para el Desarrollo de Fármacos S.A. de C.V.
🇲🇽Zapopan, Jalisco, Mexico
Scientia Investigacion Clinica S.C.
🇲🇽Chihuahua, Mexico
Sociedad de Metabolismo y Corazon
🇲🇽Veracruz, Mexico
St Elisabeth Ziekenhuis
🇳🇱Tilburg, Noord Brabant, Netherlands
UMC Utrecht, Dept. of Internal Medicine, MDL
🇳🇱Utrecht, Netherlands
Amsterdam UMC, locatie AMC
🇳🇱Amsterdam, Noord-Holland, Netherlands
Bernhoven Ziekenhuis
🇳🇱Uden, Netherlands
Samodzielny Publiczny Szpital Kliniczny nr 4 w Lublinie
🇵🇱Lublin, Lubelskie, Poland
LexMedica
🇵🇱Wroclaw, Dolnośląskie, Poland
Szpital Uniwersytecki Nr 2 im. dr J. Biziela w Bydgoszczy
🇵🇱Bydgoszcz, Kujawsko-pomorskie, Poland
NZOZ Vivamed
🇵🇱Warsaw, Mazowieckie, Poland
ZOZ Gastromed
🇵🇱Lublin, Lubelskie, Poland
Topolowa Medicenter
🇵🇱Krakow, Małopolskie, Poland
Medicenter Nowy Targ
🇵🇱Nowy Targ, Małopolskie, Poland
NZOZ Formed
🇵🇱Wadowice, Małopolskie, Poland
SONOMED Centrum Medyczne
🇵🇱Szczecin, Zachodniopomorskie, Poland
All-Medicus
🇵🇱Katowice, Poland
Wojewodzki Specjalistyczny Szpital w Olsztynie
🇵🇱Olsztyn, Poland
Twoja Przychodnia - Szczecinskie Centrum Medyczne
🇵🇱Szczecin, Poland
Gastromed Kopoń Zmudziński I Wspólnicy Spółka Jawna Specjalistyczne Centrum Gastrologii I Endoskopii
🇵🇱Torun, Poland
Warsaw IBD Point Profesor Kierkus
🇵🇱Warszawa, Poland
Centrum Zdrowia MDM
🇵🇱Warszawa, Poland
Centrum Medyczne NeuroProtect
🇵🇱Warszawa, Poland
PlanetMed Sp.z o.o.
🇵🇱Wroclaw, Poland
Promedica Dental Clinic
🇵🇱Bedzin, Śląskie, Poland
KO-Med Centrum Medyczne
🇵🇱Straszów, Świętokrzyskie, Poland
CCBR Clinical Research
🇷🇴Bucharest, București, Romania
MedLife Grivita
🇷🇴Bucuresti, Romania
ETG Zamość
🇵🇱Zamosc, Poland
Spitalul Clinic Colentina
🇷🇴Bucuresti, Romania
Medical rehabilitation center
🇷🇺Moscow, Russian Federation
Institutul Clinic Fundeni
🇷🇴Bucuresti, Romania
Hifu Terramed Conformal SRL
🇷🇴Bucuresti, Romania
Scientific Centre of Reconstructive and Restorative Surgery
🇷🇺Irkutsk, Irkutskaya Oblast', Russian Federation
Karelia Republican Hospital V.A. Baranova
🇷🇺Petrozavodsk, Kareliya, Respublika, Russian Federation
Nizhny Novgorod Regional Hospital N.A. Semashko
🇷🇺Nizhny Novgorod, Nizhegorodskaya Oblast', Russian Federation
Private Healthcare Institution Clinical Hospital Russian Railways - Medicine of Nizhniy Novgorod
🇷🇺Nizhny Novgorod, Nizhegorodskaya Oblast', Russian Federation
Spital Pelican Oradea
🇷🇴Oradea, Romania
Novosibirski Gastrocenter
🇷🇺Novosibirsk, Novosibirskaya Oblast', Russian Federation
Multidisciplinary Medical Clinic "Anthurium"
🇷🇺Barnaul, Russian Federation
Rostov State Medical University
🇷🇺Rostov-on-Don, Rostovskaya Oblast', Russian Federation
Scientific research center ECO-security
🇷🇺Saint Petersburg, Sankt-Peterburg, Russian Federation
Medical and Sanitary Division of Severstal
🇷🇺Cherepovets, Russian Federation
LLC MA New Hospital
🇷🇺Ekaterinburg, Russian Federation
Alliance Biomedical URAL Group
🇷🇺Izhevsk, Russian Federation
Clinical Trials Center of Medical Institute
🇷🇺Kaliningrad, Russian Federation
State Autonomous Institution of Healthcare "Republican Clinical Hospital of the Ministry of Healthcare of Republic Tatarstan
🇷🇺Kazan, Russian Federation
SIH Kemerovo Regional Clinical Hosptial
🇷🇺Kemerovo, Russian Federation
Clinical Diagnostic Center Ultramed
🇷🇺Omsk, Russian Federation
Saint Petersburg State Medical University n.a. Pavlov I.P.
🇷🇺Saint Petersburg, Russian Federation
Pokrovskaya Municipal Hospital
🇷🇺Saint-Petersburg, Russian Federation
LLC "Medicine Center SibNovoMed"
🇷🇺Novosibirsk, Russian Federation
Non-state Healthcare Institution "Roadway Clinical Hospital of OJSC Russian Railways
🇷🇺Saint-Petersburg, Russian Federation
Medical Institute REAVIZ
🇷🇺Samara, Russian Federation
SBIH City Clinical Hospital #31
🇷🇺Saint-Petersburg, Russian Federation
City Mariinskaya Hospital
🇷🇺St. Petersburg, Russian Federation
Stavropol State Medical University
🇷🇺Stavropol, Russian Federation
Yaroslavl Municipal HI Clinical Hospital #8
🇷🇺Yaroslavl, Russian Federation
Regional Hospital Dr Radivoj Simonovic Sombor
🇷🇸Sombor, Vojvodina, Serbia
Sremska Mitrovica Health Centre
🇷🇸Sremska Mitrovica, Vojvodina, Serbia
Clinical Hospital Center Zvezdara
🇷🇸Belgrade, Beograd, Serbia
University Medical Center "Bezanijska kosa"
🇷🇸Belgrade, NAP, Serbia
Clinical Center Kragujevac Gastroenterohepatology Clinic
🇷🇸Kragujevac, Serbia
KM Management
🇸🇰Nitra, Nitriansky Kraj, Slovakia
Gastro
🇸🇰Prešov, Prešovský Kraj, Slovakia
Endomed, s.r.o.
🇸🇰Vranov N. Toplou, Prešovský Kraj, Slovakia
Fakultna nemocnica s poliklinikou Roosevelta Banska Bystrica
🇸🇰Banska Bystrica, Slovakia
Univerzitna nemocnica Bratislava
🇸🇰Bratislava, Slovakia
Hospital Universitario Marqués de Valdecilla
🇪🇸Santander, Cantabria, Spain
Hospital Universitario Virgen Del Rocio
🇪🇸Sevilla, Andalucía, Spain
Hospital Universitari Son Espases
🇪🇸Palma de Mallorca, Baleares Islands, Spain
Instituto de Ciencias Médicas
🇪🇸Alicante, Spain
Hospital Universitari de Girona
🇪🇸Girona, Spain
Hospital Universitario Juan Ramon Jimenez
🇪🇸Huelva, Spain
Complexo Hospitalario Universitario A Coruña, CHUAC
🇪🇸La Coruña, Spain
Hospital Universitario La Paz
🇪🇸Madrid, Spain
Hospital De Gran Canaria Dr. Negrin
🇪🇸Las Palmas de Gran Canaria, Spain
Hospital Universitario Central de Asturias
🇪🇸Oviedo, Spain
Inselspital Bern
🇨🇭Berne, Switzerland
Kantonsspital St.Gallen
🇨🇭St.Gallen, Switzerland
Gastroenterologische Praxis Balsiger, Seibold & Partner
🇨🇭Bern, Berne, Switzerland
UniversitätsSpital Zürich
🇨🇭Zürich, Switzerland
China Medical University Hospital
🇨🇳Taichung, Taiwan
Health management center
🇨🇳Taipei, Taiwan
Acibadem Universitesi - Acibadem Kozyatagi Hastanesi
🇹🇷Kadıkoy, Istanbul, Turkey
Antalya Egitim ve Arastırma Hastanesi
🇹🇷Kocaeli, Antalya, Turkey
Ivano-Frankivsk Regional Clinical Hospital
🇺🇦Ivano-Frankivsk, Ivano-Frankivsk Region, Ukraine
Ege Universitesi Hastanesi
🇹🇷Izmir, Turkey
Kocaeli University Medical Faculty Hospital
🇹🇷Izmit, Kocaeli, Turkey
City Clinical Hospital No. 2
🇺🇦Kharkiv, Kharkivska Oblast, Ukraine
Kherson City Clinical Hospital
🇺🇦Kherson, Khersonska Oblast, Ukraine
Mersin University Medical Faculty
🇹🇷Yenişehir, Mersin, Turkey
Lviv Railway Clinical Hospital
🇺🇦Lviv, Lvivska Oblast, Ukraine
Lviv Regional Endocrinology Dispensary
🇺🇦Lviv, Lvivska Oblast, Ukraine
Medical Center of Limited Liability Company "Medical Center "Consilium Medical"
🇺🇦Kiev, Kyiv, Ukraine
Kharkiv City Student Hospital
🇺🇦Kharkiv, Ukraine
GI L.T. Malaya TI Namsu
🇺🇦Kharkiv, Ukraine
Diaservis - Medical and Diagnostic Center
🇺🇦Zaporizhia, Zaporizka Oblast, Ukraine
Communal institution of the Kyiv Regional Council "Kyiv Regional Clinical Oncology Dispensary"
🇺🇦Kyiv, Ukraine
Communal Enterprise "Odesa Regional Clinical Hospital"
🇺🇦Odesa, Ukraine
Treatment-Diagnostic Center of Private Enterprise of PPC Atsynus
🇺🇦Kropyvnytskyi, Ukraine
Kyiv Municipal Clinical Hospital #1
🇺🇦Kyiv, Ukraine
A. Novak Transcarpathian Regional Clinical Hospital
🇺🇦Uzhgorod, Ukraine
Vinnytsia RCH of Veterans of War Dept of Therapy#1 Vinnytsia M.I.Pyrogov NMU
🇺🇦Vinnytsia, Ukraine
MCIC MC LLC Health Clinic
🇺🇦Vinnytsia, Ukraine
CCH #1 Vinnytsia M.I. Pyrogov NMU Ch of Propaedeutics of IM
🇺🇦Vinnytsia, Ukraine
M.I. Pyrogov Regional Clinical Hospital
🇺🇦Vinnytsya, Ukraine
Communal Institution of Kyiv Regional Council Kyiv Regional Hospital #2
🇺🇦Zaporizhzhia, Ukraine
Queens Hospital
🇬🇧Romford, Essex, United Kingdom
Fairfield General Hospital
🇬🇧Bury, Great Britain, United Kingdom
Whipps Cross University Hospital
🇬🇧London, Surrey, United Kingdom
Morriston Hospital
🇬🇧Swansea, Swansea [Abertawe Gb-ata], United Kingdom
St James's University Hospital
🇬🇧Leeds, Vinnytsia, United Kingdom
Weill Cornell Medical College
🇺🇸New York, New York, United States
Center for Interventional Endoscopy
🇺🇸Orlando, Florida, United States
Clintheory Healthcare
🇺🇸Orlando, Florida, United States
Nola Research Works, LLC
🇺🇸New Orleans, Louisiana, United States
University of North Carolina Center for Inflammatory Bowel Disease
🇺🇸Chapel Hill, North Carolina, United States
West Edmonton Diabetes Center
🇨🇦Edmonton, Alberta, Canada
Municipal non-profit enterprise "Lviv Territorial Medical Union "Multidisciplinary Clinical Hospital of Em -T
🇺🇦Lviv, Lvivska Oblast, Ukraine
Carilion Clinic
🇺🇸Roanoke, Virginia, United States
Hospital De Fuenlabrada
🇪🇸Fuenlabrada, Madrid, Spain
Poltova Oblast Clinical Hospital IM.M.V.Sklifosovskoho
🇺🇦Poltava, Poltavska Oblast, Ukraine
General Hospital "Djordje Joanovic"
🇷🇸Zrenjanin, Vojvodina, Serbia
St Thomas' Hospital
🇬🇧Great Maze Pond, London, United Kingdom
Medizinische Universität Innsbruck
🇦🇹Innsbruck, Austria
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