Comparison of Two Doses of Edoxaban Using Different Tests (Assays) and Clinical Outcomes
- Registration Number
- NCT02964949
- Lead Sponsor
- Daiichi Sankyo
- Brief Summary
Atrial fibrillation is when the heart's two upper chambers (called atria) beat chaotically and irregularly, out of coordination with the two lower chambers (called ventricles) of the heart. This can lead to blood clots forming in the heart chamber.
Patients with atrial fibrillation will be treated with either 60 mg or 75 mg of edoxaban for up to 12 months, with a 2-4 week follow-up, after which their participation is complete.
Blood samples will be collected before the first dose of study drug (Day 0), and on Days 30, 90 and 360 (at pre dose, 1-2 hours post dose and 4-8 hours post-dose).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 607
- Meets protocol-specified criteria for qualification
- Is able to follow the protocol specified contraception methods
- Is willing and able to comply with any restrictions related to food, drink and medications
- Voluntarily consents to participate and provides written informed consent prior to any protocol-specific procedures
-
Has history or current use of over-the-counter medications, dietary supplements, or drugs (including nicotine and alcohol) outside protocol-specified parameters
-
Has signs, symptoms or history of any condition that, per protocol or in the opinion of the investigator, might compromise:
- the safety or well-being of the participant or study staff
- the safety or well-being of the participant's offspring (such as through pregnancy or breast-feeding)
- the analysis of results
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Edoxaban 75 mg Edoxaban Edoxaban 60 mg + edoxaban 15 mg orally, once daily, at the same time (preferably morning) for up to 12 months, with a 2-4 week follow-up period. If needed when the patient completes or discontinues the study, an open-label transition dose of 30 mg and 15 mg edoxaban tablets will be provided. Edoxaban 60 mg Edoxaban Edoxaban 60 mg + placebo 15 mg orally, once daily, at the same time (preferably morning) for up to 12 months, with a 2-4 week follow-up period. If needed when the patient completes or discontinues the study, an open-label transition dose of 30 mg and 15 mg edoxaban tablets will be provided.
- Primary Outcome Measures
Name Time Method Pharmacodynamics: Mean exposure with anti-Factor Xa (FXa) assay Pre-dose and after initiation of dosing on Days 30, 90, and 360 (at pre dose, 1-2 hours post dose and 4-8 hours post-dose) Exposure analysis performed with anti-FXa assay, using sodium citrate plasma samples Categories: Edoxaban and D21-2393
Pharmacokinetics: Average Concentration of Edoxaban at Steady State (Cav) After initiation of dosing on Days 30, 90, and 360 (at pre dose, 1-2 hours post dose and 4-8 hours post-dose) In pharmacokinetics, steady state means the overall intake of a drug is about equal to its elimination
Pharmacokinetics: Minimum Concentration of Edoxaban in Plasma (Cmin) After initiation of dosing on Days 30, 90, and 360 (at pre dose, 1-2 hours post dose and 4-8 hours post-dose) Cmin is a term used in pharmacokinetics that usually refers to the minimum blood plasma concentration that a drug achieves after the drug has been administered and prior to the administration of a second dose
Pharmacodynamics: Mean exposure using validated assays Pre-dose and after initiation of dosing on Days 30, 90, and 360 (at pre dose, 1-2 hours post dose and 4-8 hours post-dose) Exposure analysis performed with validated Liquid Chromatography/Tandem Mass Spectrometry/Mass Spectrometry (LC/MS/MS) assay with lithium heparin plasma.
Categories: Edoxaban and its metabolite (D21-2393)
- Secondary Outcome Measures
Name Time Method Efficacy: Number of participants with composite event 1 within 3 years Composite event 1 includes ischemic or hemorrhagic stroke/transient ischemic attack (TIA) and systemic embolic events (SEE)
Safety: Number of participants with major bleeding (including intracranial) within 3 years Major bleeding is defined per the International Society on Thrombosis and Haemostasis (ISTH) definition
Safety: Number of participants with any bleeding within 3 years Count of participants who experienced any bleeding event
Safety: Number of participants with clinically relevant bleeding within 3 years Clinically relevant bleeding is a combination of major bleeding and clinically relevant non-major (CRNM) bleeding
Efficacy: Number of participants with composite event 2 within 3 years Composite event 2 includes stroke/TIA, SEE, myocardial infarction, cardiovascular death, and major bleeding
Trial Locations
- Locations (230)
Vilnius University Hospital Santariskiu Clinic Public Institution
🇱🇹Vilnius, Lithuania
Synexus Polska Sp z o o Oddział we Wroclawiu
🇵🇱Wroclaw, Poland
FSHI "MSU of MoIA of RF of Kemerovo Region"
🇷🇺Kemerovo, Russian Federation
FFSBI The Nikiforov Russian Center of Emergency and Radiation Medicine
🇷🇺Saint Petersburg, Russian Federation
Clinical Center Bezanijska kosa
🇷🇸Belgrade, Serbia
Niska Banja
🇷🇸Niska Banja, Serbia
Clinical Center Nis
🇷🇸Nis, Serbia
Cardioconsult s r o
🇸🇰Bratislava, Slovakia
MHAT Dr Tota Venkova AD
🇧🇬Gabrovo, Bulgaria
UMHAT Alexandrovska EAD
🇧🇬Sofia, Bulgaria
Poliklinika Humanitas
🇨🇿Bilovec, Czechia
AZ Sint-Maarten
🇧🇪Mechelen, Belgium
Fakultni nemocnice Brno
🇨🇿Brno, Czechia
Universitairsitaire Ziekenhuizen Leuven
🇧🇪Leuven, Belgium
Innera s r o
🇨🇿Benesov, Czechia
MHAT Sv Pantaleymon - Pleven OOD
🇧🇬Pleven, Bulgaria
Oblastni nemocnice Kolin, a.s.
🇨🇿Kolin, Czechia
Fifth MHAT - Sofia EAD
🇧🇬Sofia, Bulgaria
Fourth MHAT - Sofia EAD
🇧🇬Sofia, Bulgaria
UMHAT 'Sveta Anna' AD
🇧🇬Sofia, Bulgaria
Clinical Hospital Dubrava
🇭🇷Zagreb, Croatia
Edumed s.r.o
🇨🇿Broumov, Czechia
CERMED
🇵🇱Bialystok, Poland
Poliklinika Masarykuv Dum, s.r.o.
🇨🇿Trutnov, Czechia
Slagelse Sygehus
🇩🇰Slagelse, Denmark
Krajska nemocnice T Bati a s
🇨🇿Zlin, Czechia
Nemocnice na Frantisku
🇨🇿Praha 1, Czechia
Oblastni nemocnice Pribram, a.s.
🇨🇿Příbram, Czechia
GK Neiroklinika
🇱🇻Riga, Latvia
Budapesti Szent Ferenc Korhaz
🇭🇺Budapest, Hungary
Amager Hospital
🇩🇰Copenhagen S, Denmark
Holbæk Sygehus
🇩🇰Holbæk, Denmark
Nykøbing F Sygehus
🇩🇰Nykøbing Falster, Denmark
PV - kardiologie s.r.o.
🇨🇿Pardubice, Czechia
Poliklinika RAVAK
🇨🇿Pribram 8, Czechia
Nemocnice Slany
🇨🇿Slany, Czechia
Principal SMO Kft
🇭🇺Baja, Hungary
Bispebjeg og Fredeiksberg Hospital
🇩🇰Copenhagen, Denmark
Grof Tisza Istvan Korhaz
🇭🇺Berettyoujfalu, Hungary
Regionshospitalet Viborg
🇩🇰Viborg, Denmark
Petz Aladar Megyei Oktato Korhaz
🇭🇺Gyor, Hungary
Clinic of GP A Lasmanis ALMA
🇱🇻Riga, Latvia
Szent Margit Korhaz
🇭🇺Budapest, Hungary
Pecsi Tudomanyegyetem
🇭🇺Pecs, Hungary
Jeruzsalemhegyi Egeszseghaz
🇭🇺Veszprem, Hungary
Jelgava Outpatient Clinic
🇱🇻Jelgava, Latvia
Elite Medicale JSC
🇱🇹Kaunas, Lithuania
FSBI Russian Cardiological Scientific and Industrial Complex of the MoH of the RF
🇷🇺Moscow, Russian Federation
Military Medical Academy
🇷🇸Belgrade, Serbia
Stredoslovensky ustav srdcovych a cievnych chorob a s
🇸🇰Banska Bystrica, Slovakia
Medicalgroup s r o
🇸🇰Kosice, Slovakia
Cherkasy Regional Cardiological Center
🇺🇦Cherkasy, Ukraine
CI Cherkasy RH of Cherkasy Regional Council
🇺🇦Cherkasy, Ukraine
GI L T Malaya Therapy National Institute of the NAMS of Ukraine
🇺🇦Kharkiv, Ukraine
Railway Transport Kharkiv CH#1 of Healthcare Center Branch of PJSC Ukrainian Railway
🇺🇦Kharkiv, Ukraine
SI NSС M D Strazhesko Institute of Cardiology of NAMSU (9102)
🇺🇦Kyiv, Ukraine
Hospital Nuestra Señora del Prado
🇪🇸Talavera de la Reina, Spain
Ivano-Frankivsk Regional Clinical Cardiology Dispensary
🇺🇦Ivano-Frankivsk, Ukraine
Corintez s.r.o
🇨🇿Prague, Czechia
Ordince pro choroby srdce a cev
🇨🇿Praha 10, Czechia
AVICENA -KARDIOLOGIE, INTERNA s.r.o.
🇨🇿Praha 1, Czechia
Kardio-Pisova sro
🇨🇿Praha, Czechia
Clinical Trials Services s.r.o
🇨🇿Uherske Hradiste, Czechia
O L V Ziekenhuis
🇧🇪Aalst, Belgium
ZNA Middelheim
🇧🇪Antwerpen, Belgium
AZ Sint-Jan Brugge
🇧🇪Brugge, Belgium
C H U Brugmann - Site Victor Horta
🇧🇪Bruxelles, Belgium
St-Franciskus Ziekenhuis
🇧🇪Heusden-Zolder, Belgium
AZ Turnhout - Campus Sint-Elisabeth
🇧🇪Turnhout, Belgium
MHAT 'Sveta Ekaterina' EOOD
🇧🇬Dimitrovgrad, Bulgaria
Medical Center Haskovo EOOD
🇧🇬Haskovo, Bulgaria
MHAT-Haskovo AD
🇧🇬Haskovo, Bulgaria
UMHAT Sv Georgi EAD
🇧🇬Plovdiv, Bulgaria
General Hospital Dr Josip Bencevic
🇭🇷Slavonski Brod, Croatia
General Hospital Dr Tomislav Bardek
🇭🇷Koprivnica, Croatia
Clinical Hospital Centre Rijeka
🇭🇷Rijeka, Croatia
Kromerizska nemocnice, a.s.
🇨🇿Kromeriz, Czechia
University Hospital center Zagreb (2110)
🇭🇷Zagreb, Croatia
Nemocnice Havlickuv Brod, p.o.
🇨🇿Havlickuv Brod, Czechia
Fakultni nemocnice u sv. Anny v Brne
🇨🇿Brno, Czechia
Kardio-Pisova, s.r.o.
🇨🇿Hradec Kralove, Czechia
Centrum pro choroby srdce a cev
🇨🇿Kromeriz, Czechia
InterKardioML s r o
🇨🇿Marianske Lazne, Czechia
Fakultni nemocnice v Motole
🇨🇿Praha 5, Czechia
Gentofte Hospital
🇩🇰Hellerup, Denmark
Herlev Hospital
🇩🇰Herlev, Denmark
Rigshospitalet
🇩🇰København Ø, Denmark
Hvidovre Hospital
🇩🇰Hvidovre, Denmark
East Tallinn Central Hospital
🇪🇪Tallinn, Estonia
Semmelweis Egyetem
🇭🇺Budapest, Hungary
Debreceni Egyetem Klinikai Kozpont (4002)
🇭🇺Debrecen, Hungary
Debreceni Egyetem Klinikai Kozpont (4025)
🇭🇺Debrecen, Hungary
Markhot Ferenc Oktatokorhaz es Rendelointezet
🇭🇺Eger, Hungary
Studium Egeszseghaz Kft
🇭🇺Kalocsa, Hungary
Csongrad Megyei Egeszsegugyi Ellato Kozpont Hodmezovasarhely-Mako
🇭🇺Hodmezovasarhely, Hungary
Bacs-Kiskun Megyei Korhaz
🇭🇺Kecskemet, Hungary
Selye Janos Korhaz
🇭🇺Komarom, Hungary
Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont
🇭🇺Szeged, Hungary
Csongrad Megyei Dr Bugyi Istvan Korhaz
🇭🇺Szentes, Hungary
Inese Cebere GP practice
🇱🇻Liepaja, Latvia
Health Centre 4
🇱🇻Riga, Latvia
Saules Seimos Medicinos Centras JSC
🇱🇹Kaunas, Lithuania
Hospital of Lithuanian University of Health Sciences Kaunas Clinics (5103)
🇱🇹Kaunas, Lithuania
Hospital of Lithuanian University of Health Sciences Kaunas Clinics
🇱🇹Kaunas, Lithuania
Cardiology and Rehabilitation Clinic JSC
🇱🇹Klaipeda, Lithuania
Centrum Opieki Zdrowotnej Orkan-Med
🇵🇱Ksawerow, Poland
Polimedica Centrum Badań Profilaktyki I Leczenia
🇵🇱Lodz, Poland
Medicome Sp z o o
🇵🇱Oswiecim, Poland
SPZOZ w Pulawach Szpital Specjalistyczny
🇵🇱Pulawy, Poland
Janusz Spyra Specjalistyczna Praktyka Lekarska
🇵🇱Ruda Slaska, Poland
Centrum Medyczne Sabamed - Rzeszów
🇵🇱Rzeszow, Poland
Centrum Medyczne Medyk
🇵🇱Rzeszow, Poland
NZOZ Pro-Cordis Sopockie Centrum Bad Kardiolog
🇵🇱Sopot, Poland
Synexus Polska Sp z o o Oddział w Warszawie
🇵🇱Warszawa, Poland
SBIH of Moscow City Clinical Hospital 17
🇷🇺Moscow, Russian Federation
City Hospital 1
🇷🇺Chelyabinsk, Russian Federation
SBIH of Novosibirsk Region Clinical Emergency Hospital 2
🇷🇺Novosibirsk, Russian Federation
SBEI HPE Orenburg State Medical University of the MoH of the RF
🇷🇺Orenburg, Russian Federation
LLC "Institute of Medical Investigations"
🇷🇺Saint Petersburg, Russian Federation
FSBI Saint-Petersburg Multidisciplinary Centre
🇷🇺Saint Petersburg, Russian Federation
SPB SHI Pokrovskaya City Hospital
🇷🇺Saint Petersburg, Russian Federation
Institute of Cardiovascular Diseases of Vojvodina
🇷🇸Sremska Kamenica, Serbia
Veria s r o
🇸🇰Bratislava, Slovakia
Medispol s r o
🇸🇰Presov, Slovakia
Interna SK s r o
🇸🇰Svidnik, Slovakia
KARDIO 1 s r o
🇸🇰Lucenec, Slovakia
Kardiologicka ambulancia Dr Kolikova
🇸🇰Povazska Bystrica, Slovakia
Hospital Virgen del Mar
🇪🇸Almeria, Spain
Hospital del Mar
🇪🇸Barcelona, Spain
Hospital General Universitario Gregorio Marañon
🇪🇸Madrid, Spain
Hospital Universitario Clinico San Carlos
🇪🇸Madrid, Spain
Complejo Hospitalario Universitario de Santiago
🇪🇸Santiago de Compostela, Spain
Hospital Universitario Puerta de Hierro Majadahonda
🇪🇸Majadahonda, Spain
SMPI Central Clinical Hospital of Ukrzaliznytsia
🇺🇦Kharkiv, Ukraine
CI of Healthcare Kharkiv CCH 8 Dept of Cardiology for Patients with MI 2 Kharkiv MA of PGE of MOHU
🇺🇦Kharkiv, Ukraine
SI Institute of General & Emergency Surgery of NAMS of Ukraine
🇺🇦Kharkiv, Ukraine
Kyiv City Clinical Hospital 1
🇺🇦Kyiv, Ukraine
Med Center 'Ok!Clinic' of International Institute of Clinical Trials LLC
🇺🇦Kyiv, Ukraine
SI Heart Institute of the MoH of Ukraine
🇺🇦Kyiv, Ukraine
CI Lutsk CCH Volyn Regional Center of Cardiovascular Pathology and Thrombolysis
🇺🇦Luts'k, Ukraine
Regional State Clinical Treatment-Diagnostic Cardiological Centre
🇺🇦Lviv, Ukraine
First CCH Cardiology Dept SHEIU Ukrainian Medical Stomatological Academy
🇺🇦Poltava, Ukraine
Multifield Medical Center of Odesa NMU (University Clinic 1)
🇺🇦Odesa, Ukraine
Transcarpathian RC Cardiology Dispensary Dept of General Cardiology SHEI Uzhgorod NU
🇺🇦Uzhgorod, Ukraine
M I Pyrogov VRCH M I Pyrogov VNMU Ch of IM 1
🇺🇦Vinnytsya, Ukraine
Hospital Quiron Barcelona
🇪🇸Barcelona, Spain
Parc Sanitari Sant Joan de Deu
🇪🇸Sant Boi de Llobregat, Spain
Hospital Universitario Virgen Macarena
🇪🇸Sevilla, Spain
Kanizsai Dorottya Korhaz
🇭🇺Nagykanizsa, Hungary
Fejer Megyei Szent Gyorgy Egyetemi Oktato Korhaz
🇭🇺Szekesfehervar, Hungary
Pauls Stradins Clinical University Hospital
🇱🇻Riga, Latvia
Regional Hospital of Ziemelkurzeme
🇱🇻Ventspils, Latvia
Obudai Egeszsegugyi Centrum Kft
🇭🇺Budapest, Hungary
General Hospital Dubrovnik
🇭🇷Dubrovnik, Croatia
Special Hospital for medical rehabilitation
🇭🇷Krapinske Toplice, Croatia
NMTH Tsar Boris III
🇧🇬Sofia, Bulgaria
University Hospital center Zagreb (2108)
🇭🇷Zagreb, Croatia
Somogy Megyei Kaposi Mor Oktato Korhaz
🇭🇺Kaposvar, Hungary
Daugavpils Regional Hospital
🇱🇻Daugavpils, Latvia
Dr D Harasimjuka GP Practice
🇱🇻Valmiera, Latvia
KLIMED Marek Klimkiewicz
🇵🇱Lomza, Poland
Synexus Polska Sp z o o Oddzial w Katowicach
🇵🇱Katowice, Poland
Dep Clin Hosp on Station Kemerovo of OAO "Russian Railways
🇷🇺Kemerovo, Russian Federation
SBI of HE Northwestern SMU n a I I Mechnikov
🇷🇺Saint Petersburg, Russian Federation
MHAT - Pazardzhik AD
🇧🇬Pazardzhik, Bulgaria
MHAT - National Heart Hospital EAD
🇧🇬Sofia, Bulgaria
General Hospital Varazdin
🇭🇷Varazdin, Croatia
North Estonia Medical Centre Foundation
🇪🇪Tallinn, Estonia
Dr R Eglite's Private practice
🇱🇻Kuldiga, Latvia
KARDIOMED Janczska Kociwska Ostki PodckaRekrzSp
🇵🇱Elblag, Poland
Gabinet Internistyczno-Kardiologiczny Dr n. med. Jacek Nowak
🇵🇱Libiaz, Poland
Indywidualna Specjalistyczna Praktyka Lekarska B Busz-Papiez
🇵🇱Szczecin, Poland
TSHI Altay Territorial Cardiologocal dispensary
🇷🇺Barnaul, Russian Federation
Ultramed
🇷🇺Omsk, Russian Federation
Budai Irgalmasrendi Korhaz
🇭🇺Budapest, Hungary
Uzsoki Utcai Korhaz
🇭🇺Budapest, Hungary
Jessa Ziekenhuis - Campus Virga Jesse
🇧🇪Hasselt, Belgium
C H R de la Citadelle
🇧🇪Liege, Belgium
SHATC Pleven EAD
🇧🇬Pleven, Bulgaria
UMHAT 'Dr Georgi Stranski' EAD
🇧🇬Pleven, Bulgaria
Second MHAT - Sofia AD
🇧🇬Sofia, Bulgaria
General Hospital Zadar
🇭🇷Zadar, Croatia
Clinical Hospital Sveti Duh
🇭🇷Zagreb, Croatia
Dr Arvo Rosenthal LLC
🇪🇪Tallinn, Estonia
Tartu University Hospital
🇪🇪Tartu, Estonia
Belgyogyaszati es Kardiologiai Maganrendelo
🇭🇺Bekescsaba, Hungary
SzSzB Megyei Korhazak es Egyetemi Oktatokorhaz
🇭🇺Nyiregyhaza, Hungary
Klaipeda Republican Hospital Public Institution
🇱🇹Klaipeda, Lithuania
Synexus Polska SCM Sp z o o Gdansku
🇵🇱Gdansk, Poland
KO-MED Centra Kliniczne Zamosc
🇵🇱Zamosc, Poland
FSBIH SPb Clinical Hospital of RAS
🇷🇺Saint Petersburg, Russian Federation
StP SHI Clinical hospital of St Luka
🇷🇺Saint Petersburg, Russian Federation
SHI "Center of Occupational Pathology"
🇷🇺Saint Petersburg, Russian Federation
DIAMETABOL s r o
🇸🇰Bratislava, Slovakia
CI Zaporizhzhia Cl Hosp 10 Dept of Therapy SI ZMA of PGE of MoHU
🇺🇦Zaporizhzhya, Ukraine
O F Herbachevskyi Regional Clinical Hospital of Zhytomyr RC
🇺🇦Zhytomyr, Ukraine
SHATC Cardiolife OOD
🇧🇬Varna, Bulgaria
MHAT-Plovdiv AD
🇧🇬Plovdiv, Bulgaria
UMHAT 'Tsaritsa Yoanna - ISUL' EAD
🇧🇬Sofia, Bulgaria
Clinical Hospital Center Sestre Milosrdnice
🇭🇷Zagreb, Croatia
Zala Megyei Szent Rafael Korhaz
🇭🇺Zalaegerszeg, Hungary
Dr Iveta Neniske GP Practice
🇱🇻Jekabpils, Latvia
Kaunas Clinical Hospital Public Institution
🇱🇹Kaunas, Lithuania
Indywidualna Specjalistyczna Praktyka Lekarska w Dziedzinie Kardiologii lek med Krzysztof Cymerman
🇵🇱Gdynia, Poland
Synexus Polska Sp z o o Oddzial w Gdyni
🇵🇱Gdynia, Poland
Grazyna Pulka Specjalistyczny Osrodek ALL-MED
🇵🇱Krakow, Poland
Wojewódzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii im. M. Kopernika w Łodzi
🇵🇱Lodz, Poland
FSBI "Scientific-research Institute for Complex Problems of cardiovascular disease"
🇷🇺Kemerovo, Russian Federation
SPb SBIH City Hospital 38 n a N A Semashko
🇷🇺Pushkin, Russian Federation
SBI of Ryazan region Regional Clinical Cardiological Dispensary
🇷🇺Ryazan', Russian Federation
SBEI HPE Smolensk State Medical University of the MoH of the RF
🇷🇺Smolensk, Russian Federation
Clinical Center of Serbia
🇷🇸Belgrade, Serbia
Clinical Center Kragujevac
🇷🇸Kragujevac, Serbia
SI NSС M D Strazhesko Institute of Cardiology of NAMSU (9116)
🇺🇦Kyiv, Ukraine
CI Odesa Regional Clinical Hospital Regional Center of Cardiosurgery
🇺🇦Odesa, Ukraine
Bajcsy-Zsilinszky Korhaz es Rendelointezet
🇭🇺Budapest, Hungary
Pavlov First Saint Petersburg State Medical University
🇷🇺Saint Petersburg, Russian Federation
LLC Medical Institute on Krestovsky
🇷🇺Saint Petersburg, Russian Federation
FSBI Research Institute for Cardiology of Siberian Branch RAMS
🇷🇺Tomsk, Russian Federation
Ivano-Frankivsk RCCD of MHU Dept of Arterial Hypertension SHEI Ivano-Frankivsk NMU
🇺🇦Ivano-Frankivsk, Ukraine
CI Central City Hospital 2 of Zhytomyr
🇺🇦Zhytomyr, Ukraine
North-West Federal Medical Research Center n a V A Almazov
🇷🇺Saint Petersburg, Russian Federation
SPb SBIH City Hospital 15
🇷🇺Saint Petersburg, Russian Federation
SBIH of Yaroslavl region Regional Clinical Hospital
🇷🇺Yaroslavl', Russian Federation
Clinical Center Dr Dragisa Misovic Dedinje
🇷🇸Belgrade, Serbia
Dedinje Cardiovascular Institute
🇷🇸Belgrade, Serbia
Alian s r o
🇸🇰Bardejov, Slovakia
MEDIVASA s r o
🇸🇰Zilina, Slovakia
Kyiv CCH #12 Dept of Therapy O.O.Bogomolets NMU
🇺🇦Kyiv, Ukraine
Nyiro Gyula Korhaz - Orszagos Pszichiatriai es Addiktologiai Intezet
🇭🇺Budapest, Hungary