Pulmonary Rehabilitation in Interstitial Lung Disease - a Multi-Centre, Single-Blinded Randomised Controlled Trial
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 56
- 试验地点
- 4
- 主要终点
- Functional exercise capacity
研究概览
简要总结
Interstitial lung disease (ILD) is a highly disabling group of conditions including idiopathic pulmonary fibrosis (IPF), acute and chronic interstitial pneumonias, connective tissue diseases and sarcoidosis. People with ILD frequently experience breathlessness on exertion, which limits their ability to undertake daily activities. People with ILD report very poor quality of life due to low levels of physical functioning and vitality, and high levels of breathlessness and fatigue. There are few treatments for ILD and those that are available have limited impact on quality of life.
The aim of this study is to assess the effects of Pulmonary Rehabilitation, which consists of specialised exercise training for people with lung disease, on exercise capacity and quality of life in people with ILD. We hypothesis that exercise training will result in reduced dyspnoea, improved exercise tolerance and enhanced quality of life.
详细描述
Interstitial lung disease (ILD) is a highly disabling group of conditions including idiopathic pulmonary fibrosis (IPF), acute and chronic interstitial pneumonias, connective tissue diseases and sarcoidosis. People with ILD frequently experience breathlessness on exertion, which limits their ability to undertake daily activities and reduces health-related quality of life.Available treatments for ILD have proved largely ineffective, offering no improvement in survival and demonstrating only limited impact on quality of life.
Aims of the Research
- Evaluate the effects of Pulmonary Rehabilitation on exercise capacity and quality of life in patients with ILD
- Determine the physiological response to Pulmonary Rehabilitation in patients with ILD
- Determine the relationship between the aetiology and severity of ILD and the effects of Pulmonary Rehabilitation.
Comparisons: 8 weeks exercise training compared to control group (maximal exercise capacity, functional exercise capacity, dyspnoea, quality of life).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single
入排标准
- 年龄范围
- 40 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Stable medical therapy
- •Dyspnoea on exertion following maximal treatment
排除标准
- •A history of syncope on exertion
- •Too unwell to attend the hospital for exercise training
- •Any other comorbidities which would prevent exercise training
- •Previous Pulmonary Rehabilitation in the last 12 months
结局指标
主要结局
Functional exercise capacity
次要结局
- Maximal exercise capacity
- Health-related quality of life
- Dyspnoea