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临床试验/NCT01598389
NCT01598389已完成不适用

Eating Behaviors Among Weight-Discordant Siblings

University of Pennsylvania2 个研究点 分布在 1 个国家目标入组 94 人开始时间: 2008年10月最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
94
试验地点
2
主要终点
Energy intake

研究概览

简要总结

The purpose of this study was to compare weight-discordant siblings in eating in the absence of hunger, caloric compensation, and the quality of their habitual diet. The investigator hypothesized that, within families and controlling for age differences, overweight and obese siblings would show greater eating in the absence of hunger, poorer caloric compensation, and poorer diet quality (e.g., increased percent of energy from fat and caloric beverages) compared to normal-weight siblings.

详细描述

The study used a discordant sibling design to compare putative obesity-promoting eating traits among siblings, 5-12 years, who were raised in the same household, but were discordant for weight status (normal-weight: BMI-for-age between 5 and less than the 85th percentile; overweight/obese: BMI-for-age greater or equal to the 85th percentile). Forty-seven pairs of same-sex siblings (boys and girls) were recruited from the greater Philadelphia area to participate in a 4-week study during which their eating behaviors and body composition were assessed. The study tested the hypotheses that overweight/obese, compared to normal-weight, siblings exhibit 1) a weaker ability to compensate for calories, 2) a greater susceptibility towards eating in the absence of hunger, and 3) habitual dietary intakes that favor increased dietary energy density (kcal/g) and increased %energy derived from fat and caloric beverages. The use of a behavioral genetics design to study eating phenotypes among siblings is a unique approach to elucidate shared and non-shared environmental influences that can contribute to variations in weight status during childhood.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Crossover
主要目的
Prevention
盲法
Single (Participant)

入排标准

年龄范围
5 Years 至 12 Years(Child)
性别
All
接受健康志愿者

入选标准

  • same-sex;
  • weight discordant (normal-weight vs. overweight/obese);
  • meet age criteria;
  • like most foods that were served in the study.

排除标准

  • serious medical conditions or medication use known to affect appetite, food intake and body weight;
  • developmental or psychiatric conditions;
  • food allergies or nutrient intolerances (including lactose intolerance).

结局指标

主要结局

Energy intake

时间窗: Up to 4 weeks

%COMPX, EAH, dietary intake variables

次要结局

  • Body composition(Single assessment at Week 4)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Tanja Kral

Assistant Professor

University of Pennsylvania

研究点 (2)

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