Optimal Dose of Dexmedetomidine for Laryngeal Mask Airway Insertion During Propofol Induction
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 22
- 试验地点
- 1
- 主要终点
- successful insertion of LMA
研究概览
简要总结
The investigators attempted to determine the optimal dose of dexmedetomidine required for the successful insertion of LMA during propofol induction without a neuromuscular blocking agent.
详细描述
After a predetermined bolus dose of dexmedetomidine was injected over 2 min, anesthesia was induced with propofol 2.0 mg/kg. After confirming the loss of eyelash reflex and the bispectral index (BIS) score decreased below 60, the insertion of LMA was attempted.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •ASA I-II patients undergoing general anesthesia for short elective surgery (<1 hr)
排除标准
- •G-E reflux
- •obesity (BMI>30)
- •anticipated difficult airway
研究组 & 干预措施
dexmedetomidine
After intravenous infusion of dexmedetomidine for 2 min, propofol 2.0 mg/kg was administrated. And laryngeal mask airway device was inserted(LMA # 3,4).
干预措施: dexmedetomidine (Drug)
dexmedetomidine
After intravenous infusion of dexmedetomidine for 2 min, propofol 2.0 mg/kg was administrated. And laryngeal mask airway device was inserted(LMA # 3,4).
干预措施: propofol (Drug)
dexmedetomidine
After intravenous infusion of dexmedetomidine for 2 min, propofol 2.0 mg/kg was administrated. And laryngeal mask airway device was inserted(LMA # 3,4).
干预措施: laryngeal mask airway (LMA) (Device)
结局指标
主要结局
successful insertion of LMA
时间窗: from baseline to 2 min after insertion of LMA (participants will be followed for the duration of anesthetic induction, an expected average of 10 min).
the response of patients to the insertion of LMA (classified as either 'movement' or 'no movement') during infusion of dexmedetomidine and propofol.
次要结局
未报告次要终点
研究者
Jong Yeop Kim
Associate professor
Ajou University School of Medicine