NL-OMON25618
Recruiting
N/A
Postural instability and gait disability: related but separable manifestations of Parkinson’s disease
Donders Institute for Brain, Cognition and BehaviorCentre for Cognitive NeuroimagingRadboud University Medical Centre, Nijmegen, The Netherlands0 sites50 target enrollmentTBD
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- Donders Institute for Brain, Cognition and BehaviorCentre for Cognitive NeuroimagingRadboud University Medical Centre, Nijmegen, The Netherlands
- Enrollment
- 50
- Status
- Recruiting
- Last Updated
- last year
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Parkinson's disease patients
- •right\-handed men/women of age \> 18 years.
- •written informed consent
- •idiopathic PD, according to the UK Brain Bank Criteria.
- •disease severity 2\.5, 3 or 4 on the Hoehn \& Yahr scale (gait and/or balance disorders but still able to walk/stand independently.
- •gait and/or balance impairments that remain present during an optimal ON state, i.e. after a challenge with a supramaximal levodopa dosage. For this purpose, we will use criteria used previously in neurosurgery studies by our collaborators in Grenoble, and define ‘gait impairment’ as a UPDRS part III score ≥2 for the Gait item. Similarly, postural instability will be defined as a UPDRS III score ≥2 for the Pull test item, or a score ≥2 for the item ‘Falls unrelated to freezing’ of the UPDRS part II.
- •right\-handed men/women of age \> 18 years
- •written informed consent
Exclusion Criteria
- •Parkinson disease patients
- •patients with levodopa\-induced gait or balance disorders (e.g., levodopa\-induced freezing of gait). We will therefore exclude patients who score greater on levodopa than off levodopa on the gait, balance or freezing items of the UPDRS. • failure to lay still for 90 minutes in the scanner (for example due to head tremor or medication\-induced excessive movement)
- •failure to stand/walk independently
- •other causes of clinically relevant gait difficulties (eg, orthopedic or vestibular disorders)
- •contra\-indications for MR scanning (eg, clautrophobia)
- •other neurological disorders such as stroke in history or a psychiatric disease
- •depression
- •cognitive impairment (MMSE \<26\).
- •severe comorbidity (eg cancer)
- •pregnancy
Outcomes
Primary Outcomes
Not specified
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