NL-OMON25618招募中不适用
Postural instability and gait disability: related but separable manifestations of Parkinson’s disease
Donders Institute for Brain, Cognition and BehaviorCentre for Cognitive NeuroimagingRadboud University Medical Centre, Nijmegen, The Netherlands0 个研究点目标入组 50 人开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 50
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
入选标准
- •Parkinson's disease patients
- •right-handed men/women of age > 18 years.
- •written informed consent
- •idiopathic PD, according to the UK Brain Bank Criteria.
- •disease severity 2.5, 3 or 4 on the Hoehn & Yahr scale (gait and/or balance disorders but still able to walk/stand independently.
- •gait and/or balance impairments that remain present during an optimal ON state, i.e. after a challenge with a supramaximal levodopa dosage. For this purpose, we will use criteria used previously in neurosurgery studies by our collaborators in Grenoble, and define ‘gait impairment’ as a UPDRS part III score ≥2 for the Gait item. Similarly, postural instability will be defined as a UPDRS III score ≥2 for the Pull test item, or a score ≥2 for the item ‘Falls unrelated to freezing’ of the UPDRS part II.
- •right-handed men/women of age > 18 years
- •written informed consent
排除标准
- •Parkinson disease patients
- •patients with levodopa-induced gait or balance disorders (e.g., levodopa-induced freezing of gait). We will therefore exclude patients who score greater on levodopa than off levodopa on the gait, balance or freezing items of the UPDRS. • failure to lay still for 90 minutes in the scanner (for example due to head tremor or medication-induced excessive movement)
- •failure to stand/walk independently
- •other causes of clinically relevant gait difficulties (eg, orthopedic or vestibular disorders)
- •contra-indications for MR scanning (eg, clautrophobia)
- •other neurological disorders such as stroke in history or a psychiatric disease
- •depression
- •cognitive impairment (MMSE <26).
- •severe comorbidity (eg cancer)
- •pregnancy
- •poor eyesight
- •failure to lay still for 90 minutes in the scanner (for example due to head tremor or medication-induced excessive movement)
- •failure to stand/walk independently
- •causes of clinically relevant gait/balance difficulties (eg, orthopedic or vestibular disorders)
- •contra-indications for MR scanning (eg, claustrophobia).
- •any neurological disorders such as stroke in history or a psychiatric disease
- •depression
- •cognitive impairment (MMSE <26).
- •severe comorbidity (eg cancer)
- •pregnancy
- •poor eyesight
研究者
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