NCT03920735Unknown不适用
Retrospective Non-interventional Analysis of Opportunistic Infections in Immunocompromised and Frail Patients
University Hospital, Strasbourg, France1 个研究点 分布在 1 个国家目标入组 1,000 人开始时间: 2017年3月15日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 1,000
- 试验地点
- 1
- 主要终点
- Short- and long-term survival, overall and in specific subgroups of patients
研究概览
简要总结
The analysis of a cohort of consecutive non-selected patients from the Strasbourg University Hospital, and therefore representative of the real life, will allow better identifying the risk factors for these infections (by comparison with a cohort of patient with similar conditions of immunosuppression and no infection) and improving the diagnosis and therapeutic management.
The primary objective is to identify prognosis factors affecting survival in patients with opportunistic infections
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Short- and long-term survival, overall and in specific subgroups of patients
时间窗: Short term : 6 months
次要结局
- Risk factors predisposing to opportunistic infections - age - gender - Type of work - Location - Tobacco use(first day of opportunistic infection)
- Identification of baseline prognosis factors affecting the 3 months survival(first day of opportunistic infection)
- Identification of baseline prognosis factors affecting the 6 months survival(first day of opportunistic infection)
- Description of imaging patterns opportunistic infections: analysis of chest CT-scan and cerebral CT-scan and MRI by radiologists(at first day of infection and up to 12 weeks)
- Assessment of performance of Aspergillus galactomannan detection test in serum(at onset and up to 1 week)
- Prognosis factors in patients with opportunistic infection affecting the response to antimicrobial therapy (using response criteria defined by EORTC/MSG)(first day of opportunistic infection)
- Response rate(at 1, 3 and 6 months)
- Incidence of specific opportunistic infections in different host groups(evolution of a 20-year-period)
- Assessment of performance of Aspergillus galactomannan detection test in bronchoalveolar lavage(at onset and up to 1 week)
研究者
研究点 (1)
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