Acetic acid chromoendoscopy for detection of neoplastic Barrett's esophagus
- Conditions
- Barrett's esophagus
- Registration Number
- NL-OMON25059
- Lead Sponsor
- St. Antonius Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 3268
18 years of age or older
-Diagnosis of Barrett’s esophagus undergoing surveillance gastroscopy
-Signed consent for the use of patient data
-Previous treatment for esophageal neoplasia (endoscopic resection, photodynamic therapy, argon plasma coagulation, radiofrequency ablation)
-Referral from other centers with suspected or known dysplasia for assessment and endoscopic intervention
-Obvious visible cancers at gastroscopy other than esophageal adenocarcinoma (i.e. gastric cancer, or esophageal squamous cell carcinoma)
-Known dysplasia or intensified endoscopic surveillance because of previously diagnosed dysplasia
-Prior esophagectomy
-Active esophagitis LA grade C or higher, precluding endoscopic biopsies (patients can be included after adequate treatment)
-Esophageal varices precluding endoscopic biopsies
-Coagulation disorders precluding endoscopic biopsies
-Allergy to acetic acid
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Overall neoplasia detection rate (defined as the percentage of patients with either targeted or standardized random biopsies containing LGD, HGD or EAC).
- Secondary Outcome Measures
Name Time Method 1.Neoplasia detection rate stratified by degree of neoplasia in biopsies (LGD, HGD, EAC).<br>2.Neoplasia detection rate in of targeted biopsies only (defined as the percentage of patients with targeted biopsies containing LGD, HGD and EAC). <br>3.Duration of endoscopy.