NCT00948558Unknown不适用
Citrate Pharmacokinetics in Healthy Individuals and Critically Ill Patients and the Application of Regional Citrate Anticoagulation in Continuous Renal Replacement Therapy(RCA-CRRT).
适应症
试验速览
- 阶段
- 不适用
- 入组人数
- 40
- 试验地点
- 1
研究概览
简要总结
- To compare the differences of citrate pharmacokinetics in healthy individuals and critically ill patients as well as the influential factors.
- To validate a pharmacokinetic model which has been established in a formal paper.
- To create a safe and effective RCA-CRRT protocol.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •healthy individuals, none-pregnant
- •diagnosed with acute renal failure according to RIFLE criteria
- •ARF with hepatic insufficiency
- •ARF with MODS or sepsis
- •within informed consent
排除标准
- •used drugs with citrate within one week
- •infused with blood,plasma or platelet or undergone plasma exchange therapy within 48 hours
- •serious alkalosis with PH>7.55
- •serious lactic acidosis
- •not in resuscitation state
研究者
研究点 (1)
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