The Differences of Muscle Activity Between Patients With COPD and Healthy Adults

• Conditions: Chronic Obstructive Pulmonary Disease
• Interventions: Other: no intervention

• Registration Number: NCT04146948
• Lead Sponsor: National Cheng-Kung University Hospital

Brief Summary

The purpose of this study attempts to investigate the differences and relationships of respiratory parameters, muscle activity, and dyspnea during ADL between patients with COPD and age-matched healthy participants.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2019-10-28
• Study First Submitted QC: 2019-10-29
• Study First Posted: 2019-10-31
• Study Start: 2020-01-22
• Status Verified: 2021-03
• Last Update Submitted: 2021-03-31
• Last Update Posted: 2021-04-01
• Primary Completion: 2021-12
• Study Completion: 2021-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• 40 years or older
• With the clinical diagnosis of COPD

Exclusion Criteria

• With the clinical diagnosis of asthma or cancer
• With cardiovascular, musculoskeletal and neurological diseases limiting physical activities in daily life
• In the unstable medical state
• MMSE under 25
• Barthel index score under 61

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
healthy group	no intervention	40 years or older, not with the clinical diagnosis of COPD
COPD group	no intervention	No intervention 40 years or older, clinical diagnosis of COPD (Global Initiative for Chronic Obstructive Lung Disease stages I to IV)

Primary Outcome Measures

Name	Time	Method
Modified Borg Scale	baseline	This is a self-reported scale to measure how much participants perceive dyspnea. The range from 0 which means no difficulty to breathe to 10 which means with maximal difficulty to breathe.
Cardiopulmonary exercise testing device	baseline	The machine analyze the breath of participants including oxygen consumption and minute ventilation volume. Oxygen consumption is reported in mL/min and minute ventilation volume is reported in L/min.
Modified Medical Research Council	baseline	This is a five-point scale to assess the severity of breathlessness.
Surface electromyography device	baseline	The surface EMG is performed to assess the maximum voluntary contraction and muscle activity of upper limb muscles and accessory inspiratory muscles during performing simulated ADL tasks. The maximal voluntary contraction (MVC) is used as the reference level of muscle activity to normalize the EMG data of performing simulated ADL tasks. The muscle activity is reported in percentage.
The clinical Chronic Obstructive Pulmonary Disease questionnaire	baseline	This is a self-reported questionnaire to measure the impact of COPD on participants' health status. The rating scores is a 7-point scale (0=no limitation, 6=totally limited).Higher scores mean the more severe impact of COPD on participants' daily living.

Secondary Outcome Measures

Name	Time	Method
EQ-5D questionnaire	baseline	This is a self-reported questionnaire for measuring generic health status

Trial Locations

Locations (1)

National Cheng-Kung University; 🇨🇳 Tainan, Taiwan