Objective Systolic Function Recuperation Assessed by Echocardiography

Completed

• Conditions: Myocardial Infarction; Left Ventricular Systolic Dysfunction; Anterior Akinesis; Apical Akinesis

• Registration Number: NCT01086124
• Lead Sponsor: Paul Farand

Brief Summary

The purpose of this study is to evaluate left ventricular systolic ejection fraction and anterior or apical akinesis 1 month and 3 months after a myocardial infarction treated with primary PCI to determine whether improvement at 1 month differs from improvement at 3 months.

Detailed Description

Not available

Study Timeline

• Study Start: 2010-03
• Study First Submitted: 2010-03-11
• Study First Submitted QC: 2010-03-11
• Study First Posted: 2010-03-12
• Primary Completion: 2012-06
• Study Completion: 2012-12
• Status Verified: 2013-07
• Last Update Submitted: 2013-07-03
• Last Update Posted: 2013-07-08

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 42

Inclusion Criteria

• Older than 18 years old
• ST elevation myocardial infarction treated with primary PCI
• Anterior or apical akinesis and left ventricular ejection fraction ≤ 45% on early echocardiography (48hours - 7 days post myocardial infarction)
• Initial ECG showing at least 1 mm ST elevation in 2 leads corresponding to the same vascular territory

Exclusion Criteria

• Known left ventricular systolic dysfunction before myocardial infarction
• Left bundle branch block
• Vital prognosis less than 6 months
• Cardiogenic shock
• Rescue PCI
• Sub-optimal echocardiographic imaging (contrast use is allowed)
• Significant valvular heart disease (moderate or severe)
• Surgical revascularization
• Pregnancy or breastfeeding
• Incapacity to provide informed consent

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Left ventricular ejection fraction recuperation 1 month post myocardial infarction	1 month post myocardial infarction	Left ventricular ejection fraction recuperation 1 month post myocardial infarction as compared with the left ejection fraction 3 months post myocardial infarction

Secondary Outcome Measures

Name	Time	Method
Anterior and apical akinesis recuperation 1 month post myocardial infarction	1 month post myocardial infarction	Anterior and apical akinesis recuperation 1 month post myocardial infarction as compared with 3 months post myocardial infarction

Trial Locations

Locations (1)

Centre hospitalier universitaire de Sherbrooke; 🇨🇦 Sherbrooke, Quebec, Canada